Source: [Chinese Academy of Sciences] Rice stripe virus (RSV) is a insect-array genus virus, which is mainly transmitted by the vector insect grey planthopper in a long-lasting and proliferating manner, resulting in serious reductions in rice yields in Southeast Asia. Recently, t

Source: [Chinese Academy of Sciences]

Rice Stripe Virus (RSV) is a insect-array genus virus, which is mainly transmitted by the vector insect grey planthopper in a long-lasting and proliferating manner, resulting in serious reductions in rice yields in Southeast Asia. Recently, the vector insect and viral genomics research group led by Cui Feng, a researcher at the Institute of Zoology, Chinese Academy of Sciences, has made important progress in the field of vector insect toxicity transmission using ash planthopper as a research system.

exosomes are a class of membrane vesicles with a diameter of 30-200 nm. They originate from intraluminal vesicles (ILVs) in multisilicate bodies (MVBs) and are released outside the cells through the fusion of the polyvesome to the plasma membrane of the cell. The classic function of the Exportin family is to transport substances from the nucleus to the cytoplasm. In addition, many members of the exportin family are detected in exosomes, but their function in exosomes has not been reported. Cui Feng's team separated the exosomes from the saliva of about 30,000 ash planthoppers carrying RSV for the first time, and found that RSV viral particles were encased in the exosomes and could be transmitted to rice to cause the disease. Interference to any link in the insect exosome system (MVB formation, protein sorting, vesicle transport and plasma membrane fusion) will greatly reduce the efficiency of virus transmission. A fragmented exportin 6 protein is transported into the salivary exosome by binding to the sorting protein VPS37a. At the same time, it acts as a "bridge" to directly interact with the RSV capsid protein, inputting RSV virions into the salivary exosome, realizing the horizontal transmission of the virus from the vector insect salivary glands to the plants. Therefore, exportin 6 plays a key role in exosome-mediated viral level transmission and is an important potential target for controlling the transmission of RSV viruses by ash planthopper. This study isolates exosomes from living insects for the first time, and discovers new functions beyond nucleoplasmic transport in the exportin family, providing a new perspective for revealing the important role of exosomes in viral transmission.

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Animals are located in the field of vector insect poison transmission

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