While many countries or regions around the world are coexisting with the virus, news of vaccine failure continues to spread. The new coronavirus mutates rapidly, greatly reducing the effectiveness of the vaccine. On the 215th, Taiwan's " Academia Sinica " Distinguished Researcher Weng Qihui was invited to the In his speech at Tainan No. 1 Middle School, his alma mater, he mentioned the progress of the team's development of a broad-effect vaccine and detailed how to use sugar molecules to develop a vaccine that can combat virus mutations. He said that he has been negotiating private technology transfer since September last year, and the current epidemic emergency , maybe a new broadly effective vaccine will be available in a year.
Weng Qihui won the Welsh Chemistry Prize last year, known as the " Nobel Prize Preview", and this year he was awarded the "Chemistry Pioneer Award" by the American Association of Chemists. The academic community believes that if the new coronavirus pneumonia broad-effect vaccine can be successfully launched, Weng Qihui A Nobel Prize is possible.
Tainan No. 1 Middle School recently celebrated its 100th anniversary. Weng Qihui, who was awarded the title of Outstanding Alumni, was invited to give a speech on the topic of "Innovation of Precision Health and Broad-Effect Vaccines", including Lai Mingzhao, academician of Academia Sinica, who is known as the "Father of Coronavirus" and Former "Legislative Yuan" Wang Jinping and others were present.
In his speech, Weng Qihui mentioned that the broad-acting vaccine developed together with his team has been developed for more than 10 years. In the past, it was mainly in response to the constant mutations of influenza virus . He hoped to find a broad-acting vaccine without having to change the vaccine every year. However, as the new coronavirus epidemic ravages the world Later, this research was immediately applied to the vaccine against and .
He pointed out that the surface of all viruses is partially covered with sugar molecules. The main purpose is to make it difficult for the body's immune system to distinguish friend from foe and achieve the goal of infecting humans. However, in order to maintain the coverage of sugar molecules, the parts with sugar molecules are not easy to mutate. The broad-effect vaccine uses the characteristics of sugar molecules to remove part of the sugar molecules of the virus, thereby developing a broad-effect vaccine that can resist mutations.
He also said that the team's research found that there are 12 segments of the spike protein on the surface of the new coronavirus that are resistant to mutation, and 10 of them are covered with sugar molecules. The developed broad-effect vaccine has been used in animal experiments and is known to remove Glycated spike protein can trigger a strong and broad B cell and T cell response, and the effect is quite good.
He said that this is a relay race. After the academic research is completed, the technology will be transferred to the industry for further human trials. He hopes that the technology transfer will be completed soon. (Xue Yang/editor)
