In January 1975, Premier Zhou attended the first session of the Fourth National People's Congress while he was ill. Before that, Premier Zhou's health was getting worse. From March to September 1975, Premier Zhou worked with tenacious perseverance. Because of the fight against the disease, he was almost skinny and bone-skinned. By September 1975, Premier Zhou's weight was only 30.5 kilograms, which can be said to be in a state of twilight years.

However, even so, Premier Zhou, who is fighting the disease, still cares about work. On September 7, Premier Zhou also took time to meet with the representative of Romanian Iliye Werdec . During this foreign guests meeting, Iliye Wildez expressed his sincere greetings to Prime Minister Zhou and wished him good health. Premier Zhou was very humorous and smiled at Ilier Wildez and said, "I have received Marx's invitation", showing the fearless spirit of a proletarian revolutionary.

September 20, in order to alleviate Premier Zhou's condition, the doctor performed a major operation on him. Before this major operation, Premier Zhou locked himself in the bathroom and wrote some very important things. The reason why I wrote these things was mainly because Premier Zhou was afraid that he would not wake up after this major operation, and he had to record them in full. Fortunately, Premier Zhou survived a major operation that lasted more than five hours and successfully woke up after the operation.
On October 24, Premier Zhou underwent another major operation. After this major operation, Premier Zhou never got out of the hospital bed again and spent the rest of his life in the hospital bed. After this operation, Premier Zhou basically didn't speak and lay on the hospital bed every day, very quiet.

Time soon came December. Entering the end of December, Premier Zhou began to fall into a coma intermittently. The doctor also knew that he had reached the last moment of his life and was prepared for the worst. One day, Premier Zhou's breathing suddenly stopped and his heart stopped beating. Because he was prepared for the worst, the doctors thought that the Prime Minister had reached the end of his life, so he notified the relevant leaders to say goodbye while rescuing the Prime Minister.
After the doctor rescued, it was found that Premier Zhou had blocked the trachea by a mouthful of phlegm this time. After sucking the phlegm out, Premier Zhou also opened his eyes. At this time, he was very clear-headed. Because it has been reported to the leader, many leaders come to the hospital to visit the Prime Minister at this time. The Prime Minister shook hands with them one by one. Although he didn't say anything, everyone could see happiness in his eyes. After all, Premier Zhou woke up again, which was really not easy.

Prince Zhou's last person to shake hands was Zhang Chunqiao. After shaking hands, Zhang Chunqiao was about to turn around and leave, but Premier Zhou had something to say to him and called his name. Premier Zhou was very weak at that time and his voice was very small, so Zhang Chunqiao didn't hear it, so Premier Zhou called out twice. This time, when the people next to him heard it, he called out Zhang Chunqiao.
Zhang Chunqiao returned to Premier Zhou. He bent down and heard Premier Zhou remind him: "You and Wenyuan should help Wang Hongwen well, he is still young." Zhang Chunqiao repeated Premier Zhou's words while expressing his statement: "Prime Minister, don't worry." There is a reason why Premier Zhou said this. At that time, Wang Hongwen was very young and in a high position, but he was addicted to drinking and was not doing his job properly. Chairman Mao had arranged for him to return to Shanghai to exercise, and let him go to Shanghai to conduct some investigation and research and accumulate experience.

Although Wang Hongwen often does wrong things, he is in that position. Premier Zhou also starts from the perspective of national construction and hopes that Zhang Chunqiao can help Wang Hongwen well. It can be seen that Premier Zhou still thinks about national construction until his death. However, what Premier Zhou didn't know was that at this time, Wang Hongwen, Zhang Chunqiao and others had formed a "Gang of Four" that harmed the country and the people. They persecuted a large number of outstanding cadres, and later they deserved it.