Recently, Li Yuchun revealed for the first time in the show that he suffered from ankylosing spondylitis. Is this disease serious? Why do you get sick? Will the progress of the disease affect life and work?
Written by/Qi Yafeng Picture and Text Editor/Chen Yongjie
New Media Editor/Fang Yongzhen
Interview expert:
Bai Yunjing (Deputy Chief Physician of the Department of Rheumatology and Immunology of Beijing Military Region General Hospital)
Zhang Zhuoli ( Chief Physician of the Department of Rheumatology and Immunology of Peking University First Hospital)
Recently, Li Yuchun revealed for the first time when he was a guest on the show that she suffered from ankylosing spondylitis, which she had never expected, and felt "petrochemical". The recurrence of the disease once reached the point where I needed to travel in a wheelchair. I couldn't even lie down and couldn't sleep.
In the entertainment industry, Jay Chou , Zhang Jiayi and Ada Choi also suffer from ankylosing spondylitis. Is this disease serious? Why do you get sick? Will the progress of the disease affect life and work?
Ankylos spondylitis is a chronic inflammatory disease
Ankylos and spondylos (abbreviated as AS disease). The former means bend (but has now evolved into fusion or adhesion), and the latter means spine.
From a medical professional perspective, ankylosing spondylitis is a chronic inflammatory disease that mainly invades the central axis joints such as the spine and sacroiliac joints. It is marked by bilateral sacroiliac arthritis (at the junction of the end of the spine and the pelvis), and can also invade the spinal process, paraspinal soft tissue, etc.
In layman's terms, under the influence of inflammation, low back pain or stiffness are its most common symptoms. As the disease progresses, the lesions will start from , hrs and back pain, and develop to the chest and cervical vertebrae. Finally, the entire spine will undergo "bamboo joint-like" changes, commonly known as "bone bridge". The spinal function is severely limited, and some patients may also evolve into severe hunchback.
Because the gradual aggravation of ankylosing spondylitis affects waist movement, some patients can see from their daily gaits that they really look stiff in their walking. At night, the patient's lumbar sacral will have aggravated pain and will be accompanied by difficulty turning over. The feeling of stiffness and straightness will be particularly severe when standing up after sitting for a long time.
This disease activity can last for several years because lumbar sacral pain and stiffness and joint dysfunction can seriously affect patients' work or quality of life. Some patients can relieve themselves after reaching a certain stage, but many patients also have joint ankylo , deformities and dysfunctions, and even cannot take care of themselves.
It is known that it is the hereditary disease
The exact cause of ankylosing spondylitis has not been fully explained in medicine, but it is currently known that it is a hereditary disease.
The onset of this disease is closely related to HLA-B27 (the B site of human leukocyte antigen). The proportion of HLA-B27 detected in normal population in my country is about 6-8%, and there will be great differences between different races and regions. However, the proportion of HLA-B27 detected by patients with ankylosing spondylitis is about 90%. Therefore, this disease is obviously hereditary.
In addition, about 10% of patients with ankylosing spondylitis are HLA-B27 negative, so HLA-B27 is only an important genetic factor, but not the only factor affecting this disease.
Other factors may also lead to the occurrence of this disease. Among them, among non-genetic pathogenic factors, there are many infections, such as intestinal flora and intestinal inflammation. According to statistics, 83% of male patients with ankylosing spondylitis were combined with prostatitis , and some scholars found that about 6% of patients with ulcerative colitis were combined with this disease. Other reports have also confirmed that the incidence of ulcerative colitis and localized enteritis among patients with ankylosing spondylitis is much higher than that of the general population, so it is speculated that ankylosing spondylitis may be related to infection.
In addition, environmental factors also play an important role, such as the continuous rainy southern climate and frequent cold catching are also one of the risk factors that induce this disease.
Ankylosing spondylitis "favors boys over girls"
Ankylosing spondylitis can occur at any age, but usually occurs at the age of 10-40. 10%-20% of patients develop the disease before the age of 16, with a peak age between 15 and 35 years old, with an average age of onset of 25 years old, while it is rare in children after the age of 50 and under the age of 8.
The ratio of male and female patients abroad was 9:1, and the domestic report was 10.6:1. It can be seen that men tend to have this disease, while women have relatively rare cases.
Due to the obvious hereditary nature of ankylosing spondylitis, celebrity Jay Chou also has the possibility of passing on the disease to his daughter. But the possibility of passing it to a daughter is smaller than that of a boy, and even if the daughter starts to have an illness, her age will be relatively late.
Studies have shown that women have an age of 6 years older than men. In addition, women have milder lesions and slower progression. They have fewer symptoms of central axis joints than men, and have better prognosis than men. They rarely have systemic symptoms such as fever, fatigue, and weight loss. Therefore, it is best for patients with ankylosing spondylitis to have a daughter.
can cause multi-organ lesions in the human body
Ankylosing spondylitis has a high incidence rate and is distributed worldwide, and is one of the most common diseases in arthritis.
The prevalence rate of people varies in different races and countries. In general, the incidence of Indians has the highest incidence, followed by white people, yellow people are lower than that of white people, and black people have the lowest incidence of . According to statistics, the incidence rate of , , , 0.2%, 0.13-0.22%, 0.2% in Japan, 0.2%, 0.09-0.44% in my country, 0.09-0.44%, and about 5 million patients.
Ankylosing spondylitis In addition to the symptoms of spinal motor dysfunction and ankylosing deformity, a few patients have peripheral arthritis as the first symptom, and are mainly large lower limb joints such as hips, knees, and ankles. Even organ diseases may occur, such as lesions in organs such as eyes, heart, lungs and kidneys. Among them, the eyes are one of the organs that are prone to involvement in this disease. It has been reported that about 25% of patients may develop uveitis; gastrointestinal involvement is also common.
In addition, studies have found that in 60% of patients with ankylosing spondylitis have subclinical intestinal inflammation under the naked eye or microscope, and these intestinal inflammations are closely related to the inflammation of Crohn's disease (Crohn's disease is an unknown intestinal inflammatory disease and can occur at any part of the gastrointestinal tract); secondly, heart valve insufficiency, IgA nephropathy, renal amyloidosis, and nervous system lesions may also occur.
Moderate exercise can relieve body stiffness
▲Asia Choi stubbornly defeated ankylosing spondylitis and successfully gave birth to two healthy The story of healthy babies, inspiring more patients who have lost confidence in treatment
According to media reports, although Jay Chou could not completely bid farewell to the pain of ankylosing spondylitis, he insisted on exercising and controlling the disease after work. Now he has been able to live in peace with ankylosing spondylitis, and it can be seen that his disease is well controlled.
It should be emphasized that after suffering from ankylosing spondylitis, it is not that you cannot exercise anymore, but that you need moderate exercise. Exercise is the key to its treatment. Among them, swimming and joint stretching exercises can relieve pain caused by anterior spine and relieve fatigue and stiffness caused by improper posture.
However, if the spine has fusion lesions or osteoporosis , vigorous exercise or contact exercise should be avoided to prevent spinal fracture .
can remind everyone that lying on your feet for 15-30 minutes before going to bed every day is effective in resisting the tendency of hunchback caused by pain and fatigue and flexion contractures of hip joint . In addition, it is recommended that patients should lie completely on their backs, sleep on hard beds, and have small and neck-length pillows when sleeping.
There is no method to completely cure this disease
There is currently no cure for the diagnosis and treatment of ankylosing spondylitis. However, if patients can diagnose and treat them in a timely manner, they can achieve the purpose of reducing inflammation, relieving symptoms, and even controlling the progress of the disease.
Specific treatment methods include general treatment and drug treatment. General treatment includes: proper exercise and physical therapy, such as movement of the chest, waist and limbs, to prevent the occurrence of spinal deformity and , etc.
drug treatment includes non-steroidal anti-inflammatory drugs, slow-acting anti-rheumatic drugs, glucocorticoid and biological agents, among which slow-acting anti-rheumatic drugs include sulfasalazine, leflunomide , methotrexate , thalidomide, etc.; biological agents are a new disease control drug, which has good anti-inflammatory and prevent disease progression. Currently, they include etanercept, adalimumab, infliximab, etc., which have a definite therapeutic effect on ankylosing spondylitis.
For advanced patients with spinal ankylosing and dysfunction, surgical treatment can be considered. For patients with severe peripheral joint lesions, joint replacement can be performed.
Tips
Early diagnosis and treatment avoid late hunchback
After late ankylosing spondylitis patients some hunchbacks hunchbacks reach 90 degrees, and they can't even see the objects in front of them, which looks very painful. And some reports say that ankylosing spondylitis will eventually develop hunchbacks, which is incorrect. Hump back condition, spinal ankle, is mainly caused by ossification of vertebral ligaments and vertebral ribs, which often lead to limited mobility of the spine and is one of the characteristics of disease progression.
If ankylosing spondylitis can be detected early, diagnosed early, actively treated, and maintained in the correct posture, the possibility of developing a hunchback will be significantly reduced. In other words, not all patients with ankylosing spondylitis will eventually develop a hunchback.
However, because ankylosing spondylitis is mostly hiding, it is sometimes difficult to diagnose early.
For patients under the age of 40, especially men, this disease should be highly suspected when the following symptoms occur. Please seek medical treatment immediately:
. Back discomfort appears, lasting for several weeks or months, which may be accompanied by morning stiffness, which worsens after rest, and improves after activity;
2. Asymmetrical lower limbs large arthritis;
3. Heel pain , sole pain, buttock pain, etc.;
4. Ophthalmitis with or without arthritis;
5. Anterior curvature, lateral curvature and leaning of the spine are restricted;
6. Thoracic expansion is limited.
(This article was originally published in April 2016, and the pictures in the article are from the Internet)
Produced by: Science Popularization Central Kitchen
Producer: Beijing Science and Technology News | Beike Media
