patients can find out that they have polycystic disease early, the condition is not particularly serious. If the patient has no other factors that are not conducive to conception, usually after treatment, it is possible to try to get pregnant naturally. With the help of a doctor, it is also possible naturally Conception, but if the condition is serious or there are other factors that are not conducive to conception, then after treatment, you may want to choose IVF for your child.
Whether it is natural conception or in vitro assisted pregnancy, due to the impaired endometrial receptivity, the implantation rate of embryos is low, the abortion rate is high, and the poor endometrial receptivity is mainly related to progesterone Of abnormal secretion. The main function of
progesterone:
1, proper amount of progesterone can relax the uterine muscles and reduce the activity ability, which is conducive to the growth and development of uterine pregnant eggs in the uterine cavity.
2, progesterone is derived from the ovary. Similarly, there are progesterone receptors on endometrial epithelial cells and mesenchymal cells. After progesterone binds to the progesterone receptor on the endometrium, it can promote the transformation of the proliferative endometrium into The secretory membrane prepares the fertilized egg for implantation.
3, progesterone can close the cervix, reduce the thickness of mucus, and reduce the degree of stringiness.
Decreased endometrial receptivity in PCOS patients:
studies have found that poor endometrial receptivity in PCOS patients is mainly related to nonovulation, decreased progesterone concentration, and increased androgen or insulin levels. In addition, research results indicate that low progesterone, poor estrogen antagonism caused by progesterone resistance, increased inflammation, and endometrial remodeling may be one of the important reasons for the decline in endometrial receptivity in polycystic patients. The mechanism of
progesterone resistance: The mechanism of
endometrial progesterone resistance is complicated. There is no clear research conclusion at present, and a lot of research is still needed for in-depth discussion. How does
polycystic patients usher in a good pregnancy?
For polycystic patients who need to conceive, after polycystic treatment has achieved certain results, in addition to improving endocrine and metabolic abnormalities through exercise, weight loss and drugs, it is also necessary to intervene in endometrial-related expression genes through treatment to improve the uterus Endometrial receptivity conditions, so that polycystic patients usher in a higher probability of good pregnancy, while reducing the probability of miscarriage after pregnancy.
The above content is for understanding and reference only. Please refer to the doctor's guidance for specific treatment methods.
If you have any questions or experiences you want to share with you,
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