Early stage lung cancer, especially stage I lung cancer, does not have lymph node metastasis or distant metastasis, so chemotherapy or radiotherapy is basically not required after surgery.
But it does not mean that patients with stage I lung cancer can sit back and relax, and there are many cases of distant metastasis within one year. The case in this article is that the brain metastasis appeared immediately after 6 months after the operation of early lung cancer. Compared with other organs, brain metastasis is more malignant.
In addition to traditional radiotherapy and chemotherapy, cellular immunotherapy has also shown a certain effect in controlling the progression of brain metastases.
In November 2018, Mr. Zhang found a high metabolic nodule at the apex of the right lung during physical examination at the time. Consider peripheral lung cancer and undergo surgical resection. The postoperative pathology was lung adenocarcinoma , but no involvement, no lymph node metastasis, no EGFR mutation, stage pT1bN0M0 stage I, no adjuvant chemotherapy . Focus on regular review.
In May 2019, after half a year, the MR showed a left frontal lobe lesion, and the brain metastasis operation was performed. The pathology confirmed brain metastasis after the operation. After that, pemetrexed + carboplatin chemotherapy for 5 cycles.
In May 2020, one year later, a re-examination of MR showed that there was another ring-shaped enhancement in the medial brain parenchyma.Bevacizumab + liposomal paclitaxel + carboplatin was performed for 1 cycle, followed by 13 times of TOMO knife radiotherapy.
The experience of two brain metastases left Mr. Zhang's heart lingering. Mr. Zhang hopes that in addition to frequent chemotherapy, there can be a new method to curb the rate of tumor progression and delay the time of metastasis. It is ideal if there is no recurrence or metastasis.
>>>After learning about Mr. Zhang’s medical history, the Tsinghua cell therapy team analyzed that: The barrier is difficult to reach by NKT cells, and radiotherapy is ideal.
l But for new lesions that may appear in the future, whether it is the brain or other organs, NKT cell immunotherapy can play a preventive role.
In August 2020, Mr. Zhang received 1 course/month of NKT cell immunotherapy.
▲ MR imaging findings of the head: After radiotherapy of the metastasis at the left frontal-parietal junction,The size in October 2020 is about 5mm, and the size in January 2021 is about 8mm, which is slightly larger than before (the size of 2020-5 is about 1.1×1.0cm, and imaging images are not provided). The review in May 2021 will consider the center as postoperative disability. There is a little edema zone around the cavity, and no obvious progress is seen.
As of July 2021, in one year, Mr. Zhang has undergone 10 courses of NKT cell immunotherapy. Re-examination of the cranial MR showed a small edema zone around the metastasis at the left frontal-parietal junction, which should be caused by radiotherapy, and there was no obvious progress.
CT of the chest showed no signs of recurrence after the operation of the right upper lobe; CT of the abdomen was generally normal; the spirit, diet, and sleep were normal, and the quality of life was good. The score was 76.5 points
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