Recently, Central South University Cancer Institute Xiong Wei and Professor Zeng Chaoyang, as co-corresponding authors, published an original study titled "Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2" in the international oncology journal Molecular Cancer online paper. Doctoral student Mo Yongzhen and postdoctoral fellow Wang Yumin are the co-first authors.
The incidence of nasopharyngeal carcinoma is low in most parts of the world, but it has a high incidence in Southeast Asia and southern my country . Hunan is one of the high incidence areas of nasopharyngeal cancer. The pathogenesis of nasopharyngeal carcinoma is closely related to genetic background, Epstein-Barr virus infection and environmental carcinogens. Early symptoms are not obvious, and it is very prone to invasion and metastasis; a large number of genes are involved in the occurrence and development of nasopharyngeal carcinoma, but its specific pathogenesis is still far away Not clarified. Screening and identifying genes closely related to the pathogenesis of nasopharyngeal carcinoma and clarifying their mechanism of action are of great value for the prevention and treatment of nasopharyngeal carcinoma.
circular RNA is a new type of non-coding RNA (that is, unlike the classic messenger RNA used to guide protein coding and synthesis), it is more stable than the conventional RNA due to its special ring structure. With the development of next-generation sequencing technology, more and more circular RNAs have been identified, and a large number of circular RNAs are closely related to common human diseases. Therefore, circular RNAs have become the frontiers and hotspots of biomedicine research in recent years. . At present, more than 30,000 circular RNAs have been discovered, but the function of most circular RNAs is still unclear, and even fewer have been studied in nasopharyngeal carcinoma.
The team of Prof. Wei Xiong and Professor Chaoyang Zeng adopted high-throughput sequencing and bioinformatics data mining strategies,A number of circular RNAs with significantly altered expression in nasopharyngeal carcinoma have been identified and conducted in-depth research. has obtained a series of original discoveries. In this paper published in the journal Molecular Cancer, they found that the circular RNA circRNF13 is highly expressed in the normal nasopharyngeal epithelium, and can bind to and stabilize the SUMO2 mRNA, and promote the glucose transporter through SUMOylation and ubiquitination The degradation of GLUT1 inhibits the carcinogenesis of nasopharyngeal epithelium. In nasopharyngeal carcinoma, the expression of circRNF13 is inhibited, and the expression of GLUT1 is up-regulated, which provides conditions for tumor cells to take up a large amount of glucose, and promotes the proliferation, invasion and migration of nasopharyngeal carcinoma.
In addition, the team of Professor Xiong Wei and Professor Chaoyang Zeng found that the circBART2.2 cyclic RNA encoded by EB virus promotes the expression of PD-L1 is one of the mechanisms for the immune escape of nasopharyngeal carcinoma, and is the immunity of nasopharyngeal carcinoma. The treatment provides a reference, related papers were published in Cancer Research in July this year; the molecular mechanisms of circular RNA circSETD3 and circARHGAP12 promoting the invasion and metastasis of nasopharyngeal carcinoma were published in Oncogene and Cancer Letters in January this year; there is also an article about The paper on the promotion of tumor invasion and metastasis by long non-coding RNA AFAP1-AS1 was published in Signal Transduction and Targeted Therapy in June this year. related research results have been declared for a series of national invention patents, of which 24 have been authorized .
Extended reading:
Xiong Wei, Associate Dean of School of Basic Medicine, Central South University, Director of the Institute of Cancer Research, Central South University, Director of the Key Laboratory of Canceration Principles of the National Health Commission, and Key Principles of Canceration and Invasion of the Ministry of Education Deputy Director of the Laboratory," Molecular Genetics of Nasopharyngeal Carcinoma and Genomics Research" Innovation Group Leader in Hunan Province.
Research direction:
The immune escape mechanism of malignant tumors; the molecular mechanism of non-coding RNA involved in the occurrence and development of malignant tumors; the carcinogenic mechanism of Epstein-Barr virus in the pathogenesis of nasopharyngeal carcinoma.
Zeng Chaoyang is a researcher at the Cancer Institute of Central South University, a recipient of the Hunan Outstanding Youth Fund, a key young teacher of Hunan Province, Central South University "Sublimation Educational Talent", editorial board member of the British Journal of Cancer.
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Some sources of materials: Central South University News Network, Central South University Cancer Institute, etc.
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