Recently, Professor Cao Qing's team of the Infection Department of the National Children's Medical Center (Shanghai) and Shanghai Jiaotong University School of Medicine Affiliated to the School of Medicine of Shanghai Jiaotong University, teamed with the School of Agriculture and Biology of Shanghai Jiaotong University, and the team of Yuan Congli Researcher Yuan published clinical research results online in the international authoritative journal "Emerging MicrobesInfections" (influence factor 19.568). For the first time, the clinical characteristics of systemic bone damage and visceral damage in children with normal immune function " cat scratching " and elaborated in detail, and elaborated on the epidemiology, etiology, clinical characteristics and diagnosis and treatment status of Barton infection, which caused bone damage.
The number of pet cats in my country has exceeded 50 million. The spread of zoonotic diseases by pets is an important public health and safety risk point in modern cities. Cat scratch disease is one of the most important zoonotic diseases transmitted by pets. It is caused by the invasion of Hansebal's whole body after being scratched and bitten by cats. The clinical manifestations are changeable, mainly characterized by drainage lymphadenitis, accompanied by symptoms such as fever and fatigue.
is mostly self-limiting for adults with normal immune function, but the symptoms of cat scratching in children are generally serious, which can lead to eye syndrome and deep organ infection. Due to the limited clinical understanding of cat scratch disease and the detection technology for Bartonite has not yet been commercialized, cat scratch disease is easily misdiagnosed and misdiagnosed. For example, the continuous lymphadenitis formed by cat scratch disease is very likely to be misdiagnosed as lymphoma , further increasing the clinical diagnosis and treatment burden of the disease.
The Department of Infectious Diseases of Shanghai Children's Medical Center admitted a 9-year-old girl with repeated fever for more than one month. During the MRI scan, she found abnormal bones throughout the body and liver and spleen lesions. She was suspected of being a malignant tumor many times during the early diagnosis.
After a comprehensive examination, other infectious diseases and tumors were ruled out. The doctor initially judged that it was a cat scratching disease based on the child's history of cat scratching and liver tissue biopsy pathology. Subsequently, the patient's serum and involved organs were tested for Bartonite infection through different technologies such as indirect immunofluorescence, immune tissue immunochemistry, nucleic acid detection , and Bartonite infection was finally diagnosed as acute disseminated cat scratching disease.
Bartonin infection causes systemic bone lesions in children with normal immune function. These children with bone lesions are likely to be misdiagnosed as lymphoma or osteosarcoma .
This research paper reviews the characteristics of bone damage caused by Bartonite, which will help pediatricians realize that Bartonite infection should be regarded as one of the differential diagnosis of tumor diseases when facing bone damage. In addition, there is a lack of unified standards for the diagnosis and treatment of bone damage caused by cat scratch disease. The research team of Shanghai Children's Medical Center and the School of Agricultural Biology will give full play to their respective advantages and continue to work together for the formulation of clinical diagnosis and treatment plans for cat scratch disease and the diagnosis and treatment of subsequent cases.
The first authors of this article are Wang Jing, Chen Wenjuan, Wang Meng, and Mi Qiang, and the corresponding authors of are Professor Cao Qing and Researcher Yuan Congli. Dr. Yan Zhilong, General Surgery Department of Shanghai Children's Medical Center, Dr. Wang Cuijin, Dr. Ma Jing of Pathology Department, Dr. Huang Ran, Pediatric Surgery Department of the First Affiliated Hospital of Anhui Medical University, and Weiyuan Gene Company provided support for this clinical study. The research was supported by the National Natural Science Foundation and the Shanghai Jiaotong University Medical Industry Cross Fund.
Author: Tang Wenjia Jiang Rong
Editor: Tang Wenjia
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