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PrEP Do not stop the drug without authorization
If PrEP users decide to stop the drug, what should they do? In fact, the decision to stop PrEP should be made after evaluation by a professional doctor, because stopping the drug by yourself will greatly reduce the concentration of antiviral drugs in the body and affect the prevention effect of HIV. Therefore, PrEP users must not stop the drug without authorization!
01 —
State of stopping medication
In order to ensure high HIV prevention effect, you should not stop medication without authorization after starting to use PrEP; the decision to stop medication should be made by a professional doctor after evaluation.
Common drug discontinuation situations are as follows:
1. PrEP users strongly require drug discontinuation;
2. The risk of exposure to HIV infection is reduced;
3. The side effects of drugs cannot tolerate;
4. The medication compliance is still poor after evaluation and education;
5. Confirm that you have been infected with HIV.
02 —
Time to stop the drug
When PrEP users request to stop the drug and after evaluation and permission from professional doctors, they must stop the drug in an orderly manner according to their actual situation, and take other preventive measures to reduce the risk of HIV infection. The specific timing and operations for stopping the drug are as follows:
Take the medication daily: You should ensure that you continue to take the medication for at least 7 days after the last HIV exposure;
Take the medication as needed: You should ensure that you take the two tablets of the drug after the exposure as required, that is, take one tablet 24 and 48 hours after the last dose before the end of the last sexual activity.
03 —
Discontinuation of medication for special populations
In special circumstances, PrEP users should fully consider the impact between their own other factors/diseases and PrEP drugs and handle them properly.
Hepatitis B virus infection:
This type of PrEP user will have the risk of hepatitis B virus rebound after discontinuing TDF/FTC, resulting in a sharp deterioration of liver damage . Therefore, the Hepatology Department or an infectious disease doctor must participate in the evaluation to determine whether hepatitis B antiviral treatment is required after stopping the drug.
PrEP is suspected of HIV infection:
PrEP is suspected of HIV infection, such as acute HIV symptoms, positive test results for HIV test strips, etc., you should immediately go to a professional medical institution, Center for Disease Control and Prevention or a trained community service institution for re-examination. PrEP is not required to be discontinued before the re-examination results are issued. If the patient is diagnosed with HIV, stop the medication immediately (regardless of taking the medication daily or on demand) and initiate antiviral treatment as soon as possible. At the same time, baseline drug resistance testing for treatment should be carried out under conditions to ensure the rationality of the antiviral regimen.
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