With the improvement of living standards and the changes in dietary structure, the incidence of cardiovascular diseases in middle-aged and elderly people is also increasing, such as hypertension, coronary heart disease, arteriosclerosis, and hyperlipidemia.

With the improvement of living standards and the changes in dietary structure, the incidence of cardiovascular diseases in middle-aged and elderly people is also increasing, such as hypertension , coronary heart disease , arteriosclerosis heart disease, hyperlipidemia, etc.

. Cardiovascular disease problems have also forced many patients to take some drugs for a long time, such as statins. Common statins include simvastatin , lovastatin , fluvastatin , etc.

However, there have been recent news reports that some elderly people have checked that the liver function transaminase value is 8 times higher than the normal value of .

statin is the cornerstone drug for the treatment of cardiovascular diseases. As soon as the news came out, it caused many people's concerns. So, since statin drugs may cause damage to the liver, should patients stop taking the medicine?

statin has damaged the liver. Should the patient stop taking the medicine for this?

Many people believe that statin drugs have side effects, so after blood lipids is normal, you can reduce the dosage or stop using it yourself. If blood lipids are elevated, it can also be used to reduce blood lipids by taking it quickly.

But in fact, this approach is not feasible for . Whether the statin drug can be reduced or discontinued, it needs to be judged based on each person's physical condition and the purpose of taking the drug.

For example, some people simply have increased blood lipids, such as cholesterol exceeds the standard. Then, you can reduce the dosage or stop the medication under the guidance of a doctor after the blood lipids reach normal levels.

This is because 80% of cholesterol in the human body is synthesized by itself, and 20% comes from diet. The excessive cholesterol is mainly due to the high enzyme value of synthesized cholesterol.

statin can effectively inhibit the synthetase of human cholesterol, reduce the synthesis of cholesterol, and naturally help patients quickly reduce blood lipids. After

is discontinued, most patients can maintain normal blood lipid levels by controlling their diet through , enhancing exercise, , etc.

However, if you are atherosclerosis, should not be easily reduced or should be stopped by taking statins. This is because the goal of taking medication in this type of patients is to stabilize and reverse vascular plaques and prevent cardiovascular and cerebrovascular accidents.

Usually, after the patient's blood lipids reach normal levels, they still need to insist on taking for at least 2 years before they can consider reducing dosage or stopping the medication.

. The reason why you have to take the medicine for more than 2 years is that atherosclerotic plaque rupture , which will cause platelet aggregation to be activated, which will further lead to the onset of myocardial infarction and cerebral infarction .

The formation of atherosclerotic plaques does not last overnight, ranging from a few years to more than ten years. Therefore, although taking statins in the short term may play a role in reducing blood lipids, it will take a long time to achieve to reverse plaques .

study shows that plaque stability can be achieved by taking statins for more than 2 years, and if plaques are to be reversed, it will take more than 4 years of continuous use to achieve it.

Therefore, if there is no special situation in patients with atherosclerosis after the blood lipid standards meets the standard, it is not recommended to reduce the dosage or stop the medication.

So, for the increase in aminotransferase after taking the medicine, causing liver damage to , especially the indicators have exceeded many times. When the doctor makes it clear that the patient is indeed due to taking the medicine, rather than other factors, the patient needs to stop immediately and can communicate with his attending doctor about other treatment plans.

Although statin drugs have significant effects in the treatment of cardiovascular diseases, if the side effects cannot be paid attention to early, they may also cause serious harm to physical health. So, how should patients prevent it? How can patients prevent liver damage when taking statins?

In life, although many drugs have good effects, they inevitably have some side effects. Statins are no exception. Since its launch, they have experienced adverse reactions such as liver damage, muscle damage, and diabetes and .

However, side effects are not caused by everyone, but may cause some problems that may arise depending on each person's situation, such as liver damage. So, how to prevent it after taking the medicine?

statins are mainly used in liver due to the inhibitory effect of cholesterol synthetase, and the problem of increased aminotransferase may occur. But if it is just the increase in transaminase of , it does not mean that it is liver damage to .

Most patients usually return to normal after a brief cessation of the drug after an increase in transaminase. So, how to determine whether it causes damage to the liver?

This requires patients to check regularly during medication. By regularly monitoring on of aminotransferase index, it can be timely discovered that the effects of taking medication on the liver.

If the aminotransferase index is found to exceed three times the normal value or more during the examination, the doctor will usually recommend that the patient stop taking the medication. After waiting for the indicators to return to normal, the doctor will adjust the medication for the patient or match other treatment plans.

In addition to regular monitoring, patients should also pay attention to the drug dose .

The so-called "three parts poisonous" is that for patients who need to take statins for a long time, side effects are inevitable. Therefore, the dosage of drugs is worthy of attention.

There are currently many statins on the market. Different drugs have different side effects. When choosing statins, the patient first informs the doctor about other basic conditions of his body, and the doctor will determine the type of medication and the dosage of medication .

This can not only help the body stabilize blood lipids, but also minimize the harm caused by side effects of medication to the body, such as liver damage, muscle pain, etc.

In addition, combined with medication may also lead to adverse reactions. Although

is combined with medication, it can enhance the treatment effect of patients and reduce adverse reactions. But there are some cases. For example, when statins are used in combination with ezemaibu drug , it may cause intolerance in the patient.

statins, as a common blood lipid-lowering drug, can still be prevented in advance although there will be some adverse reactions. In addition to paying attention to the above factors, patients can also pay attention to the following precautions when taking medication on daily basis. What are the precautions for taking

statins?

Patients who take statins for a long time often encounter various problems, such as whether they can take statins the next day?

In principle, it is not possible for this problem. This is because different types of statins have different effects on the treatment of patients. However, this is not absolute.

If the patient wants to take the next day, it is recommended to pay attention to the changes in the body. If there is no physical intolerance such as nausea, nausea, fatigue, abdominal pain and diarrhea, it is proven that it is OK, or the symptoms are not serious, and the patient can also take the medication by reducing the dosage of .

Select patients who take the next day and monitor their own blood lipid indicators and liver indicators more. If the index is found to be unqualified for , then the method of combined with can also be used to reduce adverse reactions .

Some patients also pay more attention to the time of medication. Since statins can effectively treat a variety of diseases, in order to ensure the efficacy of the drug, patients do need to pay attention to the time of medication. The principle of

statins to lower blood lipids is to inhibit the synthesis of cholesterol. In this process, there is actually an enzyme that has a key existence.

It is hydroxymethylglutarate monoacyl coenzyme A. Since the strongest activity value of this enzyme is at night, patients can also choose to take statins at night to make the drug effect fully play its role. , but you need to pay attention to the type of medication you take.

In addition, patients should also avoid eating these foods during statins.

is first grapefruit .Grapefruit contains flavonoid naringin, furancoumarin, chaninin, etc. These substances can inhibit the activity of a certain cellular enzyme, which catabolizes the statin drug.

If statins are used with grapefruit at the same time, it is likely to weaken the drug's metabolic capacity, which will remain in the body in large quantities, which is equivalent to increasing the dose of the drug to the patient.

Therefore, after taking statins, try to avoid eating grapefruit. If you want to take it, it is recommended to take it 8 to 12 hours after taking the medication, and you also need to pay attention to the intake issue.

In addition to grapefruit, patients should avoid alcohol intake during statins.

This is alcohol that increases the burden on the human liver and leads to an increase in cholesterol levels in the body. If you also take statin at the same time, it will cause greater damage to the liver.

Finally, patients should also pay attention to the adjustment of dietary structure during the medication period.

The daily diet structure of patients who take statins for a long time is very important. Only by maintaining good eating habits and a light diet can effectively control blood lipids, protect the liver, and protect the overall health of the body.

, and patients with hyperlipidemia should also strengthen their exercise frequency. It is recommended to maintain 2 to 3 times a week, such as yoga, jogging, gymnastics, etc. to enhance the body's resistance, improve the body's metabolic ability, and protect overall health.

or above, the population of statins is very widespread. To effectively reduce side effects, you should pay more attention to the above points. can ensure the safety of medication and ensure the health of the body.

References

【1】Zhang Liping, Zou Hui. The effectiveness and safety of statins [J]. Chinese Journal of Healthcare Medicine .2020,22(3)

[2] Chen Chenghui. Re-understanding of the safety of statins. [J]. Strait Pharmacy. 2017,29(1)

[3] Fang Jian. 6 Notes on taking statins [J]. Family Medicine : Selection of medicines for medical treatment. 2017,0(8)