Many people have heard of the name of " metronidazole ", and toothache people are more familiar with it. They even buy it from the pharmacy whenever they have toothache. In oral diagnosis and treatment, metronidazole has a strong antibacterial effect on most anaerobic bacteria , so it is often used as a first-line medicine to relieve gingivitis , periodontal disease and other diseases.
Metronidazole as a prescription drug, what should you pay attention to during use? Friends who often use this medicine may not be very clear about some questions, so I will answer them one by one.
Who needs to be used with caution?
1. Use with caution if liver damage . Patients with severe liver hypofunction need to appropriately reduce the dosage and monitor the blood drug concentration.
2. Use with caution in people with kidney damage. If used, the dosage must be adjusted under the guidance of a doctor; if renal failure is used, the dosage must be reduced by half.
3. Use it with caution for the elderly. Because elderly patients often have liver and kidney deficiency symptoms, it may affect the metabolism of this drug.
should be strictly prohibited from using it?
1. It is prohibited for people who are allergic to this product or other nitroimidazoles.
2. It is prohibited for patients with active central nervous system diseases and blood diseases. What should I pay attention to when using
?
1. Do not drink alcohol during the period of taking this medicine and at least 3 days after stopping the medicine, because some people may experience disulfiram-like reaction .
2. A low-salt diet should be taken during medication to prevent sodium retention.
3. For those who take medication for more than 7 days, check for blood routine .
4. Do not take it in excess.
Avoid drug combination
metronidazole tablets are prone to drug interactions when combined with the following drugs, so they should avoid coadministration:
1. Avoid coadministration of warfarin and other oral anticoagulants. Because metronidazole can inhibit the metabolism of warfarin and other oral anticoagulants, the blood concentration of the latter increases, the anticoagulant effect is enhanced, and the prothrombin time is prolonged.
2. Avoid using oleracycin in combination. Because oleracycin can interfere with the effect of metronidazole to clear trichomonas vaginalis.
3. Avoid the combination of liver enzyme-induced drugs such as phenytoin sodium and phenobarbital, because the combination will enhance the metabolism of metronidazole in the liver, causing its blood drug concentration to decrease, while the metabolism of phenytoin sodium is slowed down.
4. Avoid the combination of liver enzyme inhibitors such as cimetidine . Co-administration can delay the metabolism of metronidazole in the liver and prolong the elimination half-life.
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(Gao Siyang, He Xiaojing)
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