Uncle Song is over fifty, and what he is most proud of is his body. He loves fitness , and he is very particular about his diet . He has a good figure. Looking from behind, some people believe that he is a thirty-year-old young man.
But he has been a little depressed recently. Gout has frequent attacks , and the pain is excruciating every time. The key is that he no longer eats seafood, beer and other foods that increase purine .
In order to find the cause, he did a full physical examination, and the result alarmed him: the uric acid value reached 540mol/L.
Although the gout was temporarily suppressed, Uncle Song quickly went to the nephrology department to register. Gout is only a symptom shown by the body, and the damage caused by high uric acid to the body's internal body cannot be seen.
The reason for the increase in uric acid is that he likes sweets and eats fruits and desserts almost every day. It contains a large amount of fructose. If the daily intake exceeds 35 grams, the uric acid level will increase by 15%! !
1. If you eat 35 grams of fructose every day, will uric acid increase by 15%?
Uric acid is the end product of purine metabolism. The uric acid in normal human urine is about 200mg. Every day, newly generates about 600mg of . At the same time, excretes 600mg, which is in a state of relative balance .
If the body produces too much and it is too late to be excreted, or the uric acid excretion mechanism is degraded , it will cause excessive uric acid concentration in the blood, , and the body fluids will become acidic. Over time, it will cause gout, abnormal kidney function, and other diseases.
There are many causes of excessive uric acid in the body . In addition to foods high in purine, there is another one that we often eat but are easily ignored, which is fructose.
The metabolic process of fructose is through intestine into liver , and is phosphorylated by fructokinase. During the process of acidifying , the phosphate and adenosine triphosphate in the body will be converted into adenosine monophosphate , and finally metabolized by the body into uric acid.
has Research shows that if the daily fructose intake reaches 35 grams, the uric acid level will increase by 15%! This fully demonstrates that the role of fructose in raising uric acid levels cannot be ignored.
Fructose can cause insulin resistance in the body and increase the risk of diabetes . At the same time, it reduces the body's clearance rate of uric acid, which inhibits the body's excretion of uric acid, causing an increase in uric acid.
High uric acid is very harmful to the body. In order to lower the uric acid value, many patients adopt measures such as reducing the intake of purine foods and increasing the body's metabolism , but the effect is not good.
The uric acid value remains high, what is it related to?
2. Why do people’s uric acid levels remain high?
The reason for the high uric acid value is most likely related to the slow metabolism of uric acid in the body due to excessive external intake . But the root cause of and is abnormal body function.
The secretion of in renal tubules is inhibited by and , and uric acid will gradually increase. The most common ones that affect the secretory function of renal tubules are poisoning and drug influence on . When the human body's anion transport system is abnormal, lactic acid and ketoacid substances will be produced, and these are important inhibitory factors of that affect renal tubular function. .
Therefore, daily medication should be taken under the guidance of a doctor to avoid damaging the renal tubules, causing an increase in uric acid levels and causing various pathological changes.
Reduced glomerular filtration is also one of the important reasons for the increase in uric acid value. The glomerulus is responsible for filtering nutrients in the body. The essential nutrients are transported to all parts of the body, and the remaining residue enters the bladder and large intestine and is excreted from the body.
The filtering function of the glomerulus is abnormal and cannot excrete uric acid, causing uric acid to be transported into body together with the essence nutrition . Over time, uric acid levels will rise and lead to a series of diseases.
Increased renal tubular reabsorption combined with excessive purine intake can also lead to high uric acid levels.The reabsorption function of which is far away from the location of renal tubular secretion is enhanced, which will cause patients to have polyuria , resulting in renal dehydration phenomenon. If high-purine foods are taken in at this time, the excess food will continue to accumulate in the kidneys of the human body, causing the uric acid level to increase.
This is why patients with kidney disease must reduce their intake of purine foods . If a patient has excessive uric acid, they must be treated promptly to avoid worsening of the condition.
In daily life, we can also make a preliminary judgment on whether a uric acid level test is needed based on changes in the body.
3. What are the symptoms of excessive uric acid?
The impact of excessive uric acid on health is systemic, and the common ones are as follows.
. Back pain. The kidneys are mainly responsible for excreting toxins from the body. When uric acid is high, it will increase the burden on the kidneys and also affect the detoxification function of the kidneys.
Kidney disease usually manifests itself in the lower back, so there will be back pain. In addition, there will be leg weakness, cramps, lumbar disc herniation, and other symptoms.
If the above symptoms occur, on the premise of excluding external factors, it is necessary to consider whether there is a reason for the increase in uric acid level.
. gouty arthritis .
is abnormal pain in the joints, which may even cause joint swelling, tophi, , etc. This is because uric acid enters the blood and causes blockage in the joints of the body, causing pain.
. Obesity.
Obesity is closely related to many metabolic diseases. When the concentration of uric acid in the body increases, the blood flow slows down, which affects the body's metabolism and causes obesity . Obesity will further increase the amount of metabolites in the body, causing uric acid to continue to increase , forming a vicious cycle.
4.Middle-aged and elderly patients have symptoms of hypertension, , hyperlipidemia, hyperglycemia, , and often also have problems with high uric acid levels.
When the uric acid content in the blood increases, the blood pressure will increase accordingly. If it remains high, blood abnormalities will occur, causing blood pressure, blood sugar, blood lipids and all indicators to increase.
The symptoms of "three highs" are closely related to the kidneys, and uric acid can cause abnormal kidney function.
Therefore, the level of uric acid has an impact on organs throughout the body. If we want to maintain the normal operation of various organs in the body, we must keep the uric acid value in the body within the normal range of and .
4. How to eat to keep the uric acid level in the body normal?
For people with normal uric acid levels, just pay attention to a reasonable diet and avoid overeating.
The body's metabolic function is normal, so there are no need to have too many taboos when eating. Nutrition is comprehensive . But don't overeat. Once the balance of ingested and excreted is broken, you will have to endure various dietary restrictions.
People with "three highs" and obesity are high-risk groups for uric acid abnormalities and need to pay attention to their diet.
Even if uric acid value is normal , this group of people should eat less high-purine foods , such as broth, beans, animal offal, beer, seafood, etc. At the same time, pay attention to reducing underlying diseases and maintaining weight within the normal range through drugs, diet, exercise and other methods.
Reduce fructose intake, eat less fruit, and try not to drink sugary drinks.
Fructose is not only found in fruits, but also in honey, desserts, jams, sugary drinks and so on, which all contain a lot of fructose. We discussed the impact of fructose on raising uric acid levels and therefore consuming less of it in the diet.
For people with relatively high uric acid levels, it is not necessary to fast from fruits, because the vitamins, minerals and other nutrients in fruits are also needed by the body.You can choose fruits with low fructose content such as kiwi fruit, grapefruit, strawberry, and pineapple, and pay attention to the intake of no more than 200 grams per time.
Conclusion of the article:
High uric acid value has become one of the important risk factors for the health of middle-aged and elderly people. How to control the uric acid value within the normal range is a question that everyone who pursues health should be concerned about.
A high-purine diet is not the only cause of high uric acid levels. If the daily intake of fructose exceeds 35 grams, uric acid will increase by 15%. Therefore, you must pay attention to your fructose intake in your diet, drink less or no sugary drinks, and control the uric acid concentration in the blood within a reasonable range.
Reference:
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[2 】Zhang Jing, Li Hao, Shi Jianhui, Zhang Weiping. Fructose and metabolic diseases [J]. Chinese Journal of Pathophysiology, 2020, 36(04): 735-740
[3] Wang Yu, Lin Zhijian, Nie An Zheng, Zhang Bing. The role of Glut9 in fructose-induced hyperuricemia in rats [J]. Chinese Journal of Pathophysiology, 2016, 32(12)
[4] Yamanaka Hisashi, Zhou Tingjiao. Dietary life and gout [J]. Introduction to Japanese Medicine, 2003(02):70-72
