Tians spent on 300 million lives in the 20th century, and it took nearly 200 years for humans to completely end it. In 1980, the World Health Organization officially announced the elimination of smallpox, and the most important contribution was the smallpox vaccine.
Nowadays, cancer is the most threat to health. According to statistics from the National Cancer Center, a total of 4.06 million people were diagnosed with cancer in 2016, with the death toll of 2.41 million, which is even more terrifying than COVID-19 . Is there such an vaccine, , which can also end cancer? This year, a study from China may give everyone hope.
1. After one injection, the tumor of the whole body subsided. Chinese experts successfully developed the tumor vaccine
66-year-old M (pseudonym) was unfortunate. She was diagnosed with advanced gastric cancer in 2017 and subsequently underwent surgery and chemotherapy to remove cancer cells in the body. After 8 issues after the treatment, the cancer cells in her body relapsed and had metastasized to the peritoneum and lymph nodes and . When chemotherapy was performed again, the body had serious adverse effects and had to stop the treatment.
, but at the same time she was also lucky. She participated in the clinical trial of the neoantigen vaccine Neo-MoDC at the suggestion of the doctor. She then underwent a series of tests and a 2-month subcutaneous injection of Neo-MoDC vaccine alone to activate the T-cell anti-tumor immune response. On the 65th day of the experiment, the doctor began to treat her nivolumab (PD-1, O-drug) every 14 days.
days after treatment, a "miracle" appeared! Ms. Ms. Ms. M's CA-125 (tumor marker) index decreased from 596 to 65U and ml; two weeks later, the malignant ascites in her body disappeared, and the imaging results showed that the volume of metastatic supraclavicular lymph nodes decreased by about 30%; 2 months later, all metastatic lymph nodes decreased to less than 1 cm, achieving complete remission in the lymph nodes, and the metastatic lesions of ovary also decreased by 20%; on the 231st day after receiving the vaccine, the imaging results showed that all lesions in Ms. M's body completely disappeared; on day 389, the CT result showed that the metastatic lesions of her ovary also disappeared completely. The subsequent CT review results of
showed that by October 2021, the lesions in Ms. M had resolved for more than 25 months.
This study comes from the research team of Fujian Cancer Hospital and College of Life Sciences, University of Chinese Academy of Sciences, and was published in the sub-public of Nature in June this year. The emergence of new antigen vaccines undoubtedly brings new hope to countless cancer patients. But many people have never heard of this. What kind of vaccine is this?
2. What is a cancer vaccine? How does it kill cancer cells?
cancer vaccine mainly uses tumor cell-related antigens to awaken the immune system for cancer in the human body. It can currently be divided into preventive and therapeutic two types. preventive vaccine prevents cancer by preventing and killing virus . Our common HPV vaccine belongs to this type of vaccine, while therapeutic vaccine controls and kills cancer cells by activating the body's immune function. The principle of therapeutic vaccines is to stimulate dendritic cells in the immune system through vaccines. When tumor antigens appear on the surface of these cells, cytotoxic T lymphocytes will be induced, which can be cleared against specific cancer cells. At the same time, it can also stimulate and assist T cells and secretion cells rapidly, indirectly increasing the attack power of toxic T cells on cancer cells. What are the advantages of
cancer vaccine:
Compared with traditional chemotherapy and targeted treatment, cancer vaccine has fewer side effects, which are highly safe and individualized.
"Greenwich Life Sciences" released a clinical trial involving 168 patients with breast cancer. All of these patients received GP2 vaccine treatment, and the recurrence rate was 0 during the 5 years after treatment follow-up.
Since the cancer vaccine is so effective, doesn’t this mean that cancer has been conquered by humans? Then why do many people still die of cancer?
3. There is already a cancer vaccine. Do you don’t have to be afraid of cancer in the future? Although the cancer vaccine is effective, it also has certain limitations.
Currently, most cancer vaccines are in the experimental or early clinical trial stage, and there are very few vaccines that can be launched. Currently, there are only two cancer vaccines on the market, namely the Provenge vaccine for the treatment of prostate cancer and the Cuban Cimavax vaccine for the treatment of non-small cell lung cancer .
vaccine development requires facing the problems of immune escape and endogenous/exogenous resistance during treatment. The basis of the vaccine is antigen . Nowadays, the number of antigens in the antigen library is limited, and many times the research cannot be carried out smoothly.
. The price may be very expensive
Insiders predict that the average price of a single course of cancer vaccine will be between 600,000 and 800,000 yuan, which is a huge burden for most ordinary people. Although the cancer vaccine is effective, everything is still in the R&D stage and has not really entered our lives. For ordinary people, it is the most important thing to take measures to prevent cancer in daily life.
4. For cancer, ordinary people should still prevent
In fact, it is difficult to prevent cancer. The cancer research institute under the WHO has issued 12 suggestions on preventing cancer, including Do not smoke/do not use any form of tobacco products, stay away from second-hand smoke and second-hand smoke environment, maintain your weight within a healthy range, exercise appropriately, and do not drink alcohol. The best amount of alcohol should be 0. Protect your skin from direct ultraviolet rays in daily life, and be vaccinated with cancer prevention vaccines with conditions. In daily life, prevent infection, choose non-toxic products in interior decoration, it is best to insist on breastfeeding, do not be in a polluted environment for a long time, and conduct cancer screening as soon as possible.
And these are simple and easy measures in life. The key is whether you are willing to implement it and stick to the same.
There are many people who lose their lives due to cancer every year. As ordinary people, we must actively take measures to prevent cancer. Everyone mentioned above needs to learn. #组合合合合合合合合合合合合合合# #No. 1 Weekly#
Reference:
[1] "Cancer vaccine development successfully! Do you no longer have to be afraid of cancer in the future? 》. People's Daily .2018-12-01
[2] "Can the tumor disappear with a few shots of vaccines? What is the prospect of a therapeutic cancer vaccine? 》. China Medical Tribune.2022-09-05
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