In daily life, it is very common to take medicine when you are sick. In fact, medicines are like a "double-edged sword" to human health. The safe and reasonable use of medicines is a "good medicine". On the contrary, abuse of drugs, repeated administration, self-medication, and following the trend will make drugs a "toxic medicine". There has never been a natural "elixir" in the world. The key is to use it correctly and use it reasonably.
As we all know, drugs have certain adverse reactions while exerting a therapeutic effect. Generally speaking, serious adverse reactions to drugs are relatively few, but minor adverse reactions are more common. So have common drugs such as Viagra Yinqiao Tablets, Compound Licorice Tablets, Ribavirin, Annecin, and Pidomad, which have been fermented recently on the Internet, really been banned? Can these commonly used drugs be unable to be used from now on?
Vitamin C Yinqiao Tablets
Vitamin C Yinqiao Tablets are a compound preparation of Chinese and Western medicines. The main ingredients of the medicine are honeysuckle, forsythia, licorice, etc. The ingredients of Western medicine are vitamin C, chlorphenamine ( chlorphenamine ), and acetaminophen ( paracetamol ), which has the effects of cooling and cooling, clearing heat and detoxifying. Vitamin C can enhance human resistance; primula is an anti-allergic drug, and its main adverse reaction is central inhibition; paracetamol can reduce fever, but it has certain liver toxicity, and the daily limit dose cannot exceed 4g. According to the statistical results of the "Information of Drug Adverse Reactions", there have been a total of 1,885 adverse reaction reports in the past seven years, mainly involving 48 serious cases such as the central and peripheral nervous system, digestive system, and skin, and no deaths. In fact, the incidence of adverse reactions, especially the incidence of serious adverse reactions, is not very high. In 2013, the Hong Kong Department of Health called on everyone not to buy an oral product marked as Viagra C Yinqiao tablets. It was verified that it was actually a "missing" incident. The parties involved put other cold medicines containing banned ingredients (fenaxitin, aminopyrin) into the bottle of Viagra C Yinqiao tablets, which caused this incident artificially. Therefore, everyone can still use Vitamin C Yinqiao Tablets with confidence, but they should pay attention to the possible central inhibitory effect. At the same time, do not overdose or take it for a long time, and the possibility of serious adverse reactions is still very low.
Compound licorice tablets
Compound licorice tablets are also a Chinese medicine compound preparation. The main ingredients are licorice extract powder, opioid powder, camphor, star anise oil, etc., which are used to relieve cough and expectorate phlegm. In 2014, there was a report that a Chinese were sentenced to not be allowed to enter the country within five years because they brought compound licorice tablets to the United States. The reason is that compound licorice tablets are considered banned in the United States, contain banned ingredients and are used without FDA approval. In fact, the opioid powder contained in compound licorice tablets has antitussive effects, but it has a certain addictive and respiratory depression effect. Morphine, commonly used in clinical practice, is an opioid drug and needs strict control. As early as 2005, compound licorice tablets were limited to prescription drugs in China and needed to be used under the guidance of a doctor. It is not recommended to purchase them by yourself, nor should it be used as a regular drug at home. Moreover, because this drug is addictive and should not be taken in long-term or large doses. In addition, compound licorice tablets may also cause adverse reactions such as hypokalemia, which are clinically manifested as paralysis, arrhythmia, nausea, constipation, etc.
Anacin
Anacin is a compound that combines aminopyline with sodium sulfite. It is mainly used to reduce fever in high fever. It can also be used for treatment of headache, migraine, muscle pain, dysmenorrhea and other treatments. Anaijin's antipyretic and analgesic effects are powerful and rapid. It was launched in Germany in 1922 and immediately became a popular antipyretic drug. However, with the widespread use of drugs, its adverse reactions have gradually been discovered by people, including involvement of the blood and hematopoietic system, urinary system, skin, digestive system, etc., which can cause serious consequences such as renal toxicity, rash, and granulocytopenia. This drug has a 1.1% chance of inducing granulocyte deficiency, and the onset is acute, and in severe cases it endangers the patient's life.As early as 2002, my country's drug adverse reaction monitoring center collected many adverse reactions caused by Annexin, including 11 cases of allergic shock and 7 deaths; 16 cases of blood system reactions and 1 death; 31 cases of skin and muscle reactions and 4 deaths; 17 cases of urinary system reactions and 5 deaths. Foreign countries, Sweden revoked its marketing authorization in 1974, and in 1977, the United States began to ban this drug, and more than 30 countries subsequently banned this drug. In 2013, India also banned the use of this medicine. On September 4, 1982, the former Ministry of Health issued the "Notice on Announcement of Elimination of 127 Drugs", which included "Compound Annakin Tablets" in this list of elimination drugs. However, Annakin tablets, Annakin injections, Annakin nasal drops, etc. were retained.
In fact, foreign studies have shown that Annab is used for mild and moderate pain, and the overall risk of lethality is still lower than other antipyretic analgesics. Therefore, in 1995, Sweden reapproved nearly 50mg tablets and 500mg/ml injections for short-term treatment of acute moderate and severe pain and acute moderate and severe colic after tissue injury.
In short, Anna is still allowed to be used clinically in my country. It has good antipyretic and analgesic effects and is cheap. However, this drug may lead to severe granulocyte deficiency, aplastic anemia and other consequences. Be careful when using it, and should not be used as a first-line drug for antipyretic and analgesic. You can only consider using it when other antipyretic and analgesic drugs are ineffective and the fever and pain are relatively serious. In addition, the drug can be used for short-term use to eliminate tissue damage and acute pain from surgical wounds, but attention must be paid to monitoring blood images.
Ribavirin
Ribavirin, commonly known as "virazole", is a nucleoside broad-spectrum antiviral drug. The U.S. Food and Drug Administration (FDA) only allows it to be used to treat hepatitis C, human respiratory fusion virus (RSV), and hemorrhagic fever with long-acting interferon. The "Instructions on Clinical Drug Use of Chinese Pharmacopoeia (2010 Edition)" points out that ribavirin is not suitable for patients who have not been diagnosed with respiratory syncytial virus infection by laboratory diagnosis. However, the abuse of this drug is very common in China. It is more common for diseases such as colds, fever, diarrhea, herpetic pharyngitis, hand, foot and mouth disease, and even this drug is "given" anti-tumor effects. In fact, common cold is mainly caused by viruses, and is mainly rhinovirus and coronaviruses, and is mostly self-limiting diseases. There is currently no specific antiviral drugs specifically for common colds. The early application of ribavirin aerosol spraying the nasopharynx may have certain benefits, but symptomatic treatment is generally enough.
Hand, foot and mouth disease is mainly enterovirus infection. Severe and death cases are mainly caused by enterovirus type 71 (EV-71), and is also a self-limiting disease. It is also mainly symptomatic treatment. Ribavirin can indeed be considered for severe cases of EV-71 infection. However, for influenza, neuraminidase inhibitors (such as oseltamivir, zanamivir, etc.) and M2 ion channel blockers are generally recommended. Among them, adamantine and adamantine are no longer recommended for the prevention and treatment of influenza A alone. In summary, ribavirin has strict indications when used, and not any viral disease can be used. In addition, ribavirin also has serious adverse reactions, mainly manifested as hemolytic anemia, teratogenicity, etc., so it is prohibited for pregnant women and lactating women. Clinical treatment should be carried out routine blood and liver function tests when weighing the pros and cons of using ribavirin.
Pidomad
Pidomad is an immune enhancer that can be used for recurrent infections of the upper and lower respiratory tracts, recurrent infections of the otolaryngology, urinary tract infections, gynecological infections, prevention of acute infections, etc. It is a commonly used drug in pediatrics. However, a recent article questioning it has pushed the drug to the forefront. In fact, Pidomod has not been launched in the United States and the European Union, and most of its research is still in the preclinical animal experiment stage. According to data, there is no statistical difference between it and placebo in preventing acute respiratory infection of in 3-year-old healthy children. As we all know, preschool children's immune system is still developing and maturing, so they should not be called "low immunity" and use Pidomad at will.On March 9 this year, the State Food and Drug Administration website issued the "Announcement on the Revision of the Instructions for Pidomad Preparations", which stipulates the indications of the drug as: for auxiliary treatment of chronic or recurrent respiratory infections and urinary tract infections. This drug is prohibited for patients allergic to this product, children under 3 years of age, women within 3 months of pregnancy, and patients with hereditary fructose intolerance. In addition, based on monitoring data and literature, possible adverse reactions of Pidomad are listed, such as nausea, vomiting, skin allergies, headaches, dizziness, etc. It can be seen from this that Pidomod is not a "magic medicine". It is only recommended as an auxiliary treatment for chronic or recurrent infections in China, and it must not be abused.
In short, the above 5 drugs can still be used normally in my country, but it is very important to use them reasonably and safely. As a professional pharmacist, the author is very concerned about the clinical efficacy and adverse reactions of drugs. In fact, adverse reactions are inherent attributes of drugs. There are no "magic drugs" in the world that only have therapeutic effects but no adverse reactions. It is just that some drugs have smaller adverse reactions, and some are more serious. Of course, there is no doubt that we care about the efficacy of drugs, but we still need to weigh the pros and cons in use. Only when the benefits achieved by clinical efficacy are greater than the disadvantages caused by adverse reactions, or in layman's terms, adverse reactions of drugs are known and controllable can they be used in clinical practice with confidence.
Drugs have indications, and there are many hidden dangers of arbitrary abuse, and it is even more unscrupulous to use drugs following the trend. Only by considering the individual's disease situation, basic level, and the efficacy and adverse reactions of the comprehensive drug can we truly achieve "individualized" and reasonable and safe use of drugs to protect our health!
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