The incidence rate of pertussis changes periodically, with a peak every 3 to 5 years. In the past 20 years, the incidence rate of pertussis has shown a significant upward trend in developed countries, especially countries with high vaccine coverage, and the phenomenon of "pertuss

1. Pertussis Overview

Pertussis is an acute respiratory infectious disease caused by Bauterus pertussis and is one of the important diseases that cause disease and death in children around the world. The incidence rate of pertussis changes periodically, with a peak every 3 to 5 years. In the past 20 years, the incidence rate of pertussis has shown a significant upward trend in developed countries, especially countries with high vaccine coverage, and the phenomenon of "pertussis reappears".

The reason for "reappearance of pertussis"

Source: "Epidemiology and clinical characteristics of pertussis", compiled by Huajing Industry Research Institute

Typical clinical characteristics of pertussis

2. Number of pertussis and deaths

From January to August 2020, the number of pertussis in China was 3,941 cases, and the number of deaths was 1; in 2019, the number of pertussis in China was 30,027 cases, and the number of deaths was 2.

2010-August 2020 statistics chart of pertussis in China

Data source: Bureau of Disease Control and Prevention, compiled by Huajing Industry Research Institute

2010-August 2020 statistics chart of pertussis deaths in China

Data source : Bureau of Disease Prevention and Control, Huajing Industry Research Institute compiled

related report: The "2020-2025 China's Vaccine Industry Market Operation Status and Investment Strategy Consulting Report" released by Huajing Industry Research Institute

After my country implemented planned immunization and popularized children's diphtheria and tetanus vaccination in 1978, the incidence rate has dropped significantly. In recent years, the incidence rate of pertussis has also rebounded and there are signs of local outbreaks, and atypical cases among suspected cases have also attracted much attention. In 2019, the incidence rate of pertussis in China was 2.1501/100,000, and the mortality rate was 0.0001/100,000; in 2018, the incidence rate of pertussis in China was 1.5879/100,000, and the mortality rate was 0.0001/100,000.

2015-2019 pertussis incidence trend chart in China

Data source: Bureau of Disease Prevention and Control, compiled by Huajing Industry Research Institute

2015-2019 pertussis mortality chart in China

Data source: Bureau of Disease Prevention and Control, compiled by Huajing Industry Research Institute

3. Current status of pertussis vaccination

According to the pertussis antigen preparation process, pertussis vaccine is divided into two categories: whole-cell pertussis vaccine (wP) and acellular pertussis vaccine (aP). At this stage, my country's immunization program vaccines are co-purified DTaP, and the non-immunization program vaccines that can be selected include component purification DTaPIPVHib and co-purified combined vaccine DTaPHib.

Currently, among the 194 WHO member countries or regions, 90% of the countries or regions adopt an immunization procedure with the first dose of no later than 2 months of age. my country's Children's Immunization Program (2016 Edition) stipulates that one dose of DTaP is given at 3, 4, 5 and 18 months of age, and points out that children can receive the first dose of DTaPIPVHib at 2 months of age according to the vaccine instructions. From 2009 to 2018, the rate of DTP3 in children reportedly remained above 99%.

html In the late 119th century, someone proposed the concept of transferring anti-infection immunity from mother to newborns. Domestic and foreign studies have also proved that pertussis antibodies can enter the fetus from the mother through the placenta. Compared with cocoon protection methods, vaccination of pregnant women has higher economic benefits. Therefore, some countries have begun to implement pregnancy vaccination for whooping cough vaccine to prevent infants and young children from getting infected with whooping cough, but it has not been implemented yet in China. The optimal pregnancy vaccination time for acellular pertussis vaccine so far and whether pregnancy vaccination will affect the baby's active immune response still needs further research and clarification.

Current status of administering the vaccination of acellular pertussis vaccine during pregnancy in various countries or regions

Source: "The current status of global vaccination of acellular pertussis vaccine during pregnancy"

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