At a time when three shots are generally completed, the Chinese Center for Disease Control and Prevention magazine proposed to get the second booster shot, that is, the fourth shot, and linked it with the "end of the new crown pandemic", which attracted attention.

Source: [Dahe Health News]

This article is reproduced from Jianshiju (ID: jianshiju)

The new crown vaccine will have the fourth shot?

A few days ago, the English version of the "Chinese Center for Disease Control and Prevention Weekly" (CCDC Weekly) published an article "Perspectives: Vaccinate with Confidence and Finish Strong", which affirmed the achievements made in domestic epidemic prevention and control over the past two years, and proposed that the vaccine is a key factor in ending the new crown pandemic, and it is necessary to "vaccinate the second strengthening injection" in a timely manner.

"Strengthening needle" is what the people commonly call the "third needle". At a time when three shots are generally completed, the magazine of the Chinese Center for Disease Control and Prevention proposed to get the second booster shot, and means the fourth shot, and linked it to "the end of the new crown pandemic", , which attracted attention.

The corresponding author of this view article is written by Yin Zundong, director of the Immunization Program Center of the Chinese Center for Disease Control and Prevention, and Lance Rodwald, senior consultant of the Center for Disease Control and Prevention. The authors of the article also include Feng Zijian, deputy director of the Center for Disease Control and Prevention. (CCDC Weekly is a journal managed by the National Health Commission of and compiled by the Chinese Center for Disease Control and Prevention.)

As of early August this year, the number of people who have completed the full vaccination of the new crown vaccine and strengthened vaccination in China has reached 1.2 billion and more than 800 million respectively. Although whether wants to get the "fourth shot" has caused discussions this year, it has not been confirmed.

Wu Jinglei, Director of the Shanghai Municipal Health Commission, and many other health system experts have publicly stated that whether to get the fourth injection should be determined based on actual research and the epidemic situation.

"almost certainly needs" the second dose of strengthening injection

CCDC Weekly, the core of this article is actually to summarize the role of the new crown vaccine in epidemic prevention and control.

article mentioned: Since the COVID-19 pandemic, China's continuous prevention and control policies have saved "more than 99% of the population from being infected by the COVID-19 virus and its variants." In addition, the new crown vaccine produced in China has obtained the emergency use certification of WHO , and the supply volume has reached more than 5 billion doses. "90% of Chinese people have been protected by domestic vaccines" ", and "except for the extremely rare and serious allergic reactions that all vaccines will cause, there are no serious safety problems."

However, the article is also frank that no vaccine can prevent infection and transmission very effectively: the protective effect of the vaccine will weaken over time, so no matter which vaccine it is, it needs to "maintain protection through one or more intensified doses." A data cited by the

article shows that after investigating the Omickron BA.2 outbreak in Hong Kong this year, investigators found that the homologous strengthening inactivated vaccine is "effective in preventing severe and deadly new coronary pneumonia at 98%," which is comparable to the homologous strengthening mRNA vaccine level. If there is no booster injection, the effective efficiency of inactivated vaccination is only 70%.

article believes that if you want to maintain this protective effect for a long time, "is almost certain that you need to receive a second dose of strengthening injection within the right time."

However, in many previous discussions, most experts in have been reserved about the fourth injection.

In June this year, Chief Physician Sun Xiaodong, deputy director of the Shanghai Center for Disease Control and Prevention, said in an interview with "Shanghai Huangpu" that judging from the current data, it is not certain that "how long the immunity of the second dose of enhanced injection can last, and it is not clear whether the second dose of enhanced injection can bring benefits to the general population."

Zhang Yuntao, chief scientist of Sinopharm China Biology, also expressed a similar view in an interview with " Global Times ". He believes that the current study shows that the antibody titer produced by the fourth needle will not exceed the third needle. "Combined with the current situation in China, it is worth discussing whether the 4th needle vaccination will be fully carried out at this stage."

last "10%" is the key

Once the "fourth needle" is promoted nationwide, means that at least 800 million doses of inoculation will be increased by at least 800 million doses.

According to data released by the National Health Commission, as of August 9 this year, the number of people who have completed the full vaccination of the new crown vaccine in the country reached 1.268 billion, and the number of people who have completed enhanced immunization reached 820 million.The fourth injection is carried out on the basis of the third injection, and the total vaccination volume will exceed 800 million in people who have not completed the strengthening of immunity.

This may bring new opportunities to the end of the country's new crown vaccination, and the products of related companies will also be useful.

At present, more than 90% of the population in China have received at least one dose of the new crown vaccine. Yin Zundong and others pointed out from the beginning that establishing herd immunity to through vaccination is a difficult task: no matter what type of vaccination is promoted, the last 10% are often the "hardest to complete".

This 10% of people are the "key people to be protected". is mainly the elderly, and most of them suffer from basic diseases such as hypertension, diabetes , cardiovascular and other basic diseases. Once infected, the risk will be higher. An overseas clinical study cited by the article

shows that the domestic COVID-19 vaccine has an anti-hospital rate of 80% against delta and Omickron variants, an anti-hospital rate of 86% for entering the intensive care unit, and an anti-hospital rate of 84% for fatal COVID-19 , and the vaccine has a higher effect on patients with comorbidities than patients without comorbidities.

article believes that the immunization program "needs to benefit all people who have not been vaccinated and have not been strengthened." To this end, regulators and vaccine manufacturers should also "work to eliminate contraindications to vaccination during pregnancy so that pregnant women can participate in vaccination campaigns."

"Everyone wants to return to normal life, and vaccination is the most critical link." The article said: Although it is very difficult to achieve the final 10% of the new crown vaccination, these "works are worth it."

This article comes from [Dahe Health News] and only represents the author's views. National Party Media Information Public Platform provides information release and dissemination services.

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