Recently, Xi'an Jiaotong University researchers in the internationally renowned academic journal Advanced Functional with the title of "High-efficiency photothermal/coordinated dual drugs synergistic therapy for IR780" (IR780-loaded hyaluronic acid@gossypol–Fe(III)–EGCG infinite coordination polymer nanoparticles for highly efficient tumor photothermal/coordinated dual drugs synergistic therapy) Research results were published online on Materials (IF=16.8).
Photothermal therapy (PTT) can quickly and effectively remove tumor cells in a short period of time. Researchers often load photothermal agents and drugs on carriers to perform photothermal therapy and chemotherapy for tumors. With the development of nanotechnology, this field has received continuous attention. At present, PTT has the advantages of fast treatment speed and obvious treatment effect, but it also has the disadvantages of uneven distribution of photothermal agent tumor tissue, short treatment time and inability to completely inhibit tumor recurrence. Due to the limitation of carrier materials, nanocarrier chemotherapy has the disadvantages of low drug loading, unadjusted drug ratio, single efficacy, and drug resistance. Sometimes light and heat can also destroy chemotherapy drugs. Therefore, the strategies and vectors of PTT/chemotherapy tumor combination therapy need to be improved.
Infinite Coordination Polymers (ICPs) are an infinite coordination "carrier-free nanodrug" formed by directly coordinating drugs and metal ions. The advantage of is that it does not require carrier materials, and directly uses drugs as carriers, so it has a high drug load and good thermal stability. The proportions of different drugs can be designed freely according to needs. The coordination bonds in ICPs are also characterized by low pH sensitive release. Due to the special acidic environment of the tumor, ICPs are particularly suitable for combined drug treatment of tumors.
Research found that the color of natural anti-tumor drug gossypol (gossypol) and green tea polyphenol (EGCG) becomes darker after infinite coordination with metal ions. The absorption spectrum has changed and has a certain photothermal conversion ability. After doping a certain proportion of the photothermal agent IR780, its photothermal efficiency has increased significantly from 16% to 47.8%. makes these ICPs have the ability to have both photothermal treatment and ICPs chemotherapy. The system has the characteristics of multiple uses. In addition, due to the different order of release of each drug in ICPs, tumor treatment can be carried out in different stages.
Recently, Institute of Biomedical Imaging and Application, School of Life, Xi'an Jiaotong University, , Professor Wu Daocheng, , , , based on the characteristics of infinite coordination polymers, proposed a new two-stage dual-synergistic Tumor Therapy (Two-stage Dual-synergistic Tumor Therapy), , PTT combined with two drugs, gossypol and green tea polyphenol, and chemotherapy in the second stage, 2 drugs combined with chemotherapy. To this end, the researchers doped gossypol and green tea polyphenol with Fe3+ infinite coordination polymer, 1.3% photothermal agent IR780, and then used hyaluronic acid (HA) with tumor-targeting ability as the shell, and prepared hyaluronic acid-encapsulated gossypol-Fe(III)-catechol infinite coordination polymer nanoparticles (HA@IRGFE ICP NPs) loaded with IR780 to achieve a two-stage dual-synergic tumor treatment strategy. in vitro experiments prove that HA@IRGFE ICP NPs first release IR780 and ICPs for photothermal/chemotherapy treatment, and then the two drugs in ICPs release combined with chemotherapy, achieved the effect of two-stage dual-synergy tumor treatment . Animal experiments show that the tumor suppression rate of this method of is as high as 98.7%, and the tumor recurrence rate after 60 days is only 12.5%. It has achieved efficient photothermal and dual-drug ICPs synergistic treatment of tumors. The system is composed of natural products, with extremely low toxic and side effects on normal tissues, and has broad application prospects in future tumor treatments.
Two-stage dual-cooperative tumor treatment strategy diagram
The first author of this paper is Luo Siyuan, a doctoral student at the School of Life of Xi'an Jiaotong University, Professor Wu Daocheng is the only corresponding author of , and the School of Life of Xi'an Jiaotong University is the first and only corresponding author of this paper.This research result is another important achievement of Professor Wu Daocheng's research team after infinite coordination polymer combined with chemotherapy for tumor treatment (Int J Nanomedicine2017, 12; 4085–4109, ESI high citation papers and Biomaterials2018, 154; 197-212).
This work has been funded by the National Natural Science Foundation and the National Major Scientific Instrument Equipment Project. The Analysis and Testing Center of Xi'an Jiaotong University provides a large amount of test characterization support for this work.
Wu Daocheng, Ph.D., professor and doctoral supervisor at the School of Life of Xi'an Jiaotong University. The research directions are biomaterials and tissue engineering, biomacromolecule and drug carriers.
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