Central People's Radio reporter Wan Cunling Wang Xuejie
According to China Voice's "News Zongheng" report, on October 1, local time, the 2018 Nobel Prize in Physiology or Medicine was announced. American scientist James P Allison and Japanese scientist Honjutsu (Tasuku Honjo) eventually won the award. Although the two deserved the award, it also makes us feel very sorry that the Chinese scientist Exhibition Hall passes by the Nobel Prize.
In fact, the differences between many media and scholars and the judges are mainly due to the fact that although Japanese scientist Honjutsu discovered the PD-1 antibody, it opened the door to tumor immunity research, but first stepped into the door and realized that PD-1 can be used to deal with cancer was the one that was the one that was used to treat cancer. At the press conference after the announcement of the Nobel Prize in Physiology or Medicine, a reporter asked the jury why the award was not awarded to the exhibition platform that also made outstanding contributions to the field of immunization. The jury’s answer was “We only comment on the winner candidates.”
Authoritative expert: There are three reasons for Chen Lieping’s missed the Nobel Prize
. At the first time when Chen Lieping’s missed the Nobel Prize in Physiology or Medicine, many scholars and colleagues also sighed for him. Chen Lieping’s contribution to human tumor immunotherapy is obvious to all in the academic community. So what are the reasons why he passed by the Nobel Prize? Let’s first take a look at the analysis of Wang Yuedan, deputy director of the Department of Immunology, School of Medicine, Peking University.
is mainly based on the recognition of the academic community. In fact, many people do not fully understand Teacher Chen's contribution. I think the first reason is that Professor Chen Lioping mainly completed undergraduate education and postgraduate education in mainland China. After he went abroad, he may not be able to integrate into Western culture on the one hand. That is to say, many people may feel that people have such contributions. Everyone feels jealous. I think the first is cultural differences;
Second, I think Teacher Chen's publicity has not been done very well, because he is a very practical person and found PD- The ligand of 1, the molecule that activates PD-1 - b7h1, is named by Teacher Chen. A year later, some people in the academic community, especially Honshuyu and his students, renamed b7h1, which is PDL-1, so that it can be integrated into the path of PD-1, including Alison. He is actually a person who likes publicity very much. He has a band called checkpoint "checkpoint", which includes Alison's ptla-4 and Honshuyu's PDL-1, etc. Now everyone has named them "checkpoint" and that is, checkpoint. From this perspective, Mr. Chen’s work is not as widely valued as the first two high-profile scientists. Of course, our country's Fudan University also had a prize before, which was awarded to the checkpoint discoverers. At that time, Alison and Honshuyou also won it, and Teacher Chen did not win the award. So we felt that China did not give any awards to our own awards, and it did not attract the attention of the media at that time, which also reflected the understanding of the academic community at that time; the third one of
is that Nobel Prize cannot exceed three winners. Teacher Chen discovered PDL-1, and in fact there is another molecule called PDL-2, which was discovered by another American. It is possible that if the award committee members consider whether ligands can win the prize, whether more people can win the prize, and it does not comply with the rules of the Nobel Prize; but I think Teacher Chen's contribution is to create a new direction for tumor exemption treatment, and promote monoclonal antibody drugs of pd-1 and pdl-1, which has played a very important role in tumor immunotherapy, so I think this Nobel Prize should actually be made with Teacher Chen.
Chen Lieping student: He has always been very persistent
If it weren't for passing the Nobel Prize, we might not have noticed the low-key and pragmatic Chen Lieping. Yesterday, China Voice reporter Wan Cunling interviewed Professor Chen Lieping's students. Zhang Qiuyu, currently deputy director of the Immunotherapy Institute of Fujian Medical University:
Zhang Qiuyu, deputy director of the Immunotherapy Institute of Fujian Medical University, went to the Department of Immunobiology and Cancer Research Center of Yale University in the United States from 2014 to 2015 to get in touch with Chen Lieping and his team. But in fact, as early as 10 years ago, Zhang Qiuyu had the honor to listen to his speech at Hi Fujian Medical University .
Zhang Qiuyu said: Teacher Chen graduated from our Medical University. From July 1, from July 1, he finished his undergraduate degree at our Medical University and worked as a doctor in our Union Hospital for one year. How can he get into a graduate student at Peking University and finally go out? In fact, although he left his alma mater, he was still very concerned about his alma mater and was often invited to give lectures at our alma mater. I am a major in immunology. In fact, I first met him because I heard him come back several times to give reports. My year-long study at Yale not only gave Zhang Qiuyu a deeper research on the academic field, but also had a deeper understanding of Chen Lieping's scientific research attitude.
What I felt most deeply about is that I have benefited a lot from experimental technology this year at Yale, and I have more of his philosophy on scientific research and his judgment on some theories. Immunology is a marginal discipline. He has unique insights on many theories of immunology and retrospective summary of these existing theories, and it often leads us to see more. What makes me feel the most profound is his persistence in this scientific research work and his relatively unique understanding.
According to Zhang Qiuyu, from 20 years ago to the present, the relevant textbooks for immunology have not been greatly updated. They have conducted research in situations that are not optimistic. Chen Lieping has overcome many hardships that many non-professionals cannot imagine. Chen Lieping has always adhered to his original intention on the road of scientific research.
Zhang Qiuyu said: I think he is really a scholar, loves research, loves scientific research, and is very determined about what he does, because in scientific research, we may encounter many difficulties, so he has always been very persistent. In scientific research, the most difficult thing is that you need time to wait. Teacher Chen is his determination to the work he does. I think this is also a very good personality and an aspect that is worth learning from by young scholars.
Even though he is in Yale, Chen Lieping has always cared about his alma mater. In 2013, Chen Lieping began to establish the Institute of Immunotherapy of Fujian Medical University and served as the director.
He really wants to do something for his alma mater, so he wants to form such a research team, hoping to push some of his research results to industrialization as soon as possible. Our school does not have many ready-made experiences in industrialization for reference. During the establishment process, our original intention was very good, but because of the update of personnel technology and the improvement of platform construction, it actually takes time. We started to form it in 2013 and can really start to operate normally. I think it should be around 2015 or 2016. The use is that in the past two years, we have relatively stable personnel and clear teams, and then we started to promote some projects.
Although far away in the United States, Chen Lieping is also very concerned about the progress of the Fujian Institute. Since the establishment of the Institute, Chen Lieping has first grasped the scientific research direction and the big framework. Whenever there is a problem with the experiment, he will give suggestions and guidance one by one.
Zhang Qiuyu: He often comes back, at least I want to have a guarantee once a month, and we often hold conference calls. There are many students here, and some need to provide us with new ideas, new concepts, and some things that we need to communicate frequently, because in the next step, they can often have a far-sighted vision and give us more useful guidance.
Zhang Qiuyu's opinion, although the teacher missed the Nobel Prize this time, his achievements in research in the field of tumor immunity are still undeniable.
I think its contribution to tumor immunity is quite huge, because it has put forward many concepts. It should be said that many clinical research results have verified that the theories he proposed are indeed accurate, and these theories can be applied in practice, because we are doing a lot of research, but in fact, many work may not be used in clinical practice.
Chen Lioping said in an earlier interview with the media: Chinese people are not good at telling stories and are not good at turning complex science into simple concepts for people to accept. This may be our biggest flaw. I don’t want to comment too much on the Nobel Prize, but I still hope to focus on research.
Although the chairs of the Nobel Prize Museum cannot write all the names of heroes, all the efforts made by scientists to overcome illness and explore the unknown will be remembered by history forever.
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