myocardial infarction and stroke are high worldwide. However, due to the complex hemodynamics of the blood circulation system, targeted drug delivery to damaged blood vessel sites still faces huge challenges. challenge. Studies have shown that the shape of nanocarriers affects their fate and biological functions in the body. Compared with spherical nanocarriers, non-spherical nanoparticles have stronger adhesion ability to the surface of blood vessels; the special functions of cubic nanoparticles need to be studied and confirmed, and so far little is known about them. See the research report on cubic-structured nanoformulation.
Zhang Jiwen’s research group at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, invented a cubic nanomaterial, GS5-MOFs, which is assembled into cubic nanoparticles using the medicinal excipient cyclodextrin. The blood vessels are highly targeted and will not induce normal platelet activation and have no impact on the normal blood circulation system. The results of the in vivo mouse tail docking model showed that GS5-MOFs can target the bleeding injury site and reduce the bleeding time and blood loss of mice by 90%, while the same dose of spherical cyclodextrin nanosponges (GS5-NSs) only It can reduce bleeding time by 23% and blood loss by only 7%. In addition, the targeting efficiency of GS5-MOFs to mesenteric thrombi in mice was three times that of spherical GS5-NSs, indicating that the cubic shape of GS5-MOF nanocarriers plays a crucial role in vascular targeting. Cubic GS5-MOF is not only an efficient hemostatic agent, but also serves as a drug carrier. It has broad application prospects for the targeted diagnosis and treatment of vascular-related diseases such as uncontrolled bleeding, atherosclerosis, and stroke. It is expected to improve thrombolytic drugs Therapeutic effect and reduce side effects.
This research result was published as a cover paper on Theranostics on April 13. The research was completed by doctoral candidate He Yaping, with researcher Su Yong and Dr. Li Haiyan participating in the discussion and guidance. The research work was supported by the Strategic Priority Science and Technology Project of the Chinese Academy of Sciences (XDA12050307), the National Key Research and Development Program (2016YFE0125100), and the Institute of Drug Innovation of the Chinese Academy of Sciences. Deployment scientific research project (CASIMM0120182001) and National Natural Science Foundation of China (81573392 , 81430087).
Cubic GS5-MOFs target the bleeding site to achieve efficient hemostasis
Source: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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