The main content of this report:
1. Singapore first local case of BA.2.75 "Centaur"
2. WHO : BA.2.75 "possible major immune escape"
3. Singapore reported 2 new cases yesterday The elderly died, and the overall case fatality rate dropped to 0.089%
4. ICU The number of severe patients dropped to 14, and the ICU ward occupancy rate was 4.0%
5. The number of ordinary oxygen-receiving patients increased to 68, and the number of ordinary hospitalized patients increased to 676
BA.2.75 "Centaur" appeared in Singapore for the first time Case
html On July 22, the Singapore Ministry of Health reported that there were 6 local cases of Omicron BA.2.75 for the first time.BA.2.75 is a fork of Omicron BA.2. The WHO has not yet given it a separate name, but some netizens named it "Centaur" after the constellation "Sagittarius". The nickname later became popular.
The six confirmed cases of "Centaur" in Singapore were detected by the Ministry of Health through whole-genome sequencing. All six patients were quarantined after testing positive and all had mild symptoms.
A few days ago, the Ministry of Health reported that there were two cases of Omicron BA.2.75 for the first time on July 14, both of which were imported from abroad. The two had recently traveled to India, quarantined themselves after being diagnosed, and have now recovered.
BA.2.75 is a new subtype variant of Omicron, which has spread to more than ten countries including India, Australia, Germany, the United Kingdom, Canada, and Singapore.
On the same day (July 22), the first imported case of BA.2.75 was detected in Taiwan. He was a man in his 30s who arrived in Taiwan from India. He had received 3 doses of the vaccine. On July 10, he came from India with two relatives and friends. Upon arrival, although they had negative reports before taking the flight, all three people had fever symptoms and tested positive at the airport after entry; the man tested positive for BA.2.75, and the other two companions tested positive for BA.4.
Chief Scientist of the World Health Organization:
It may indicate "significant immune evasion"
The World Health Organization is still observing BA.2.75 and has not yet included it in the list of virus strains of "concern".
However, WHO chief scientist Soumya Swaminathan said BA.2.75 appeared to have mutated in a way that could indicate "significant immune evasion," adding that it showed a "clear growth advantage" over other variants in India. ". When the highly mutating Omicron virus emerged late last year, global health authorities issued similar warnings.
The Ministry of Health of Singapore pointed out that there is currently no evidence that the toxicity and severity of BA.2.75 are different from other subspecies of Omicron.
BA.2.75 is a fork of BA.2. Compared with BA.2, its protein spike has nine mutations. Scientists are more concerned about the two mutations G446S and R493Q.
G446S may help BA.2.75 form an escape that produces antibodies against existing vaccines, while R493Q may make it easier for BA.2.75 to attach to human cells . In other words, BA.2.75 may have greater immune escape. Ability may also be more spreadable.
BA.2.75 was first discovered in India in May this year. delta was also discovered for the first time in India. However, experts have observed the current epidemic situation in India and found that BA.2.75 did not form a large wave of infection or death.
Professor Paul Tambyah, President of the Asia-Pacific Society of Clinical Microbiology and Infectious Diseases, believes that at this stage of the global epidemic, the new coronavirus should mutate to become extremely transmissible, but its toxicity will be greatly reduced, just like the 1918 Like the "Spanish Flu", from 1920 to 1957, mutated into the influenza that is common among adults.
Singapore's cumulative confirmed cases exceeded 1.64 million The growth rate of local cases dropped to 1.02
Singapore added 8,983 confirmed cases yesterday, including 8,635 local cases and 348 imported cases, bringing the total to 1,645,092 cases, exceeding 1.64 million. In addition, a total of 13,600 people have been discharged from hospitals/released from isolation.
On the same day, the moving average of local cases in the past seven days was 8,919, 170 fewer than the previous cycle.
Tonight the case growth rate should fall back to 1.0 or below
The seven-day moving growth rate of local cases has dropped to 1.02 from 1.05 the previous day, meaning that there were 100 cases in seven days in the previous stage and 102 cases in seven days in this stage; meaning that there were 102 cases in seven days in the local area Cases are still growing, but at a slower pace.
Judging from the current data trend, the epidemic in Singapore should have entered the peak flattening stage. The growth rate of cases should fall back to 1.0 or below tonight. But there should still be thousands of cases this week. Cases are increasing daily.
We have repeatedly proposed that the growth rate will fluctuate around 1.0 until it reaches herd immunity . The so-called "herd immunity" does not mean that the virus is no longer contagious, but that the speed of infection is slowed down, the severe illness rate and mortality rate are maintained at a low level, and medical resources are not overwhelmed. The people do not panic, have a calm mind, and maintain normal production and life. , learning order.
There were 2 new deaths of elderly people over 70 years old yesterday.
The overall case fatality rate dropped to 0.089%
The Ministry of Health reported 2 new deaths last night, bringing the total to 1,468. The overall case fatality rate dropped to 0.089% from 0.090% the previous day. .
All the two new death cases were elderly people in their 70s or above. They died on the 19th and 22nd of this month respectively. The recent death toll and age distribution are as follows:
By type of virus strain, Singapore has experienced the original wave of the virus, last year it entered the Delta wave, and now it is the Omicron wave. The case fatality rate of for this wave of the epidemic remains at 0.047%, and is the same as the previous day, which is half of the case fatality rate of influenza and .
The above-mentioned Omicron Rongbo is only a rough classification of the "Singapore Eye". Some of the death cases were infected with the Delta strain, but the time of death occurred during the Omicron Rongbo period, so we still include it in the Omicron Rongbo statistics. .
The original virus wave in Singapore infected mostly migrant workers in dormitories, who were in the prime of life, and two people died of the disease; the Delta wave and Omikjong wave mainly infected the community, and most of the people who died were elderly and frail.
The number of severe patients in the ICU dropped to 14.
There were 14 people in the intensive care unit in the ICU, one less than the previous day; the ICU ward occupancy rate was 4.0%.
According to age, there are 10 people in their 70s or above (-1), 2 people in their 60s (=), and 2 middle-aged people between 40 and 59 years old (=); numbers in brackets To compare today and yesterday.
According to the condition, 2 people were under oxygen infusion observation in the ICU (=), and 12 people were intubated in critical condition (-1).
Among the two people under oxygen infusion observation in the ICU, one has not been vaccinated/has not completed the full course of vaccination, and the other has completed the full course of vaccination and has received a booster shot.
Among the 12 people who were in critical condition and intubated, 3 people have not been vaccinated/have not completed the full course of vaccination, 9 people have completed the full course of vaccination, and 8 of them have received booster shots.
99.7% are asymptomatic/mild
In the past 28 days, there have been a total of 235,526 confirmed cases in Singapore, of which 99.7% are asymptomatic/mild, 0.2% have required/are currently requiring ordinary oxygen, and 0.03% have been/ Still in severe condition in ICU, 0.02% died.
Under the national vaccination plan, the proportion of the population that has completed the full course of vaccination is 93%, and the proportion of the population that has received the booster shot is 79%. People over 50 years old have been offered free vaccination with the second dose of mRNA booster shot.
The vaccination status of hospitalized patients at all levels yesterday was as follows:
The community positivity rate was 28.84%
Among the newly confirmed cases yesterday, 740 (8%) had positive PCR nucleic acid tests and 8,243 (92%) had positive ART antigen tests.
Singapore does not conduct nucleic acid testing for all employees, but instead allows the public to do antigen ART self-tests. Although antigen testing is not as sensitive as nucleic acid, it is fast, low-cost, and avoids the risk of collective testing. It is especially suitable for use in cities where epidemics have already occurred.
In addition to Singapore, many countries also adopt this model. Some countries do not conduct PCR nucleic acid testing for all employees, nor do they conduct ART antigen self-testing, such as Russia and North Korea. The Hong Kong Special Administrative Region of China originally recognized ART positive as a confirmed diagnosis, but later believed that the proportion of " false positives " was higher than , resulting in the phenomenon that confirmed data was falsely higher than . Therefore, ART positive was no longer considered a confirmed diagnosis, but had to be verified by PCR. Considered a confirmed diagnosis.
"Singapore Eye" calculated based on data from the Ministry of Health that Singapore's positivity rate was 28.84%. In other words, for every 10,000 people, 2,884 people were diagnosed.
The Ministry of Health has repeatedly pointed out that considering that many positive ART antigen self-tests are not reported, the number of infections must actually be more, and the overall positivity rate must be higher. experts have judged that the overall positive rate may have reached 70 to 80%.
The higher the positivity rate, the closer it is to herd immunity. The virus will still spread, but at a slower rate, with fewer severe cases and fewer deaths. The authorities consider not the number of infections, but severe cases and deaths when formulating policies, and will open the country to as wide a range as possible as soon as possible without risking a run on medical resources.
The number of general oxygen-receiving patients increased to 68.
The number of general in-patient patients increased to 676.
The number of general oxygen-receiving patients increased to 68, an increase of 5 from the previous day.
Among the 68 people receiving ordinary oxygen, 16 have not been vaccinated/have not completed the full course of vaccination, 52 people have completed the full course of vaccination, and 48 of them have received booster shots.
Ordinary oxygen-receiving patients use ordinary isolation wards and mask-type ventilators, which are non-invasive, do not require the establishment of artificial airways, and do not require intubation.
There are 676 ordinary patients in the isolation ward, 13 more than the previous day.
Among the 676 general hospitalized patients, 139 have not been vaccinated/have not completed the full course of vaccination, 537 have completed the full course of vaccination, of which 473 have received booster shots.
0.8% of patients with Delta infection required oxygen infusion, and less than 0.3% of patients with Omicron infection required oxygen infusion.
Overseas imports increased by 348 yesterday
Recently, confirmed cases of coronavirus have soared around the world, and a new wave of infections has emerged in many places in Europe, the United States, and Southeast Asia.
Under the influence of a new wave of epidemics in many places around the world, there were 348 new imported cases in Singapore, bringing the total to 55,409.
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