published in Chinese Journal of Dermatology , "China Melasma Diagnosis and Treatment Expert Consensus (2021 Edition)" pointed out that "Clinical staging of chloasma is divided into active phase and stable phase, and photoelectric therapy and chemical exfoliation should be avoided during active phase."
Why can’t picosecond laser be used for chloasma during active periods?
The reason is that patients with chloasma during active period are in the "diffusion" stage of melasma. In the near future, the area of the skin lesions will expand, the color will deepen, and the skin lesions will be red. This stage requires reducing surface stimulation, otherwise it may lead to worsening of melasma.
In fact, laser treatment of chloasma often has great limitations. For example, some patients have a large range of chloasma, and the treatment effect may be poor; some people may apply laser to treat it after applying decolorizing agent, which may be poor. Multiple acid brushing treatment and external treatment of spot removal drugs caused by thin skin, sensitive skin, and dilatation of skin vasculature are also not suitable for laser treatment. In addition, traditional treatment methods such as lasers treat symptoms but not root causes, and the prone to recurrence of chloasma is also a major problem that has troubled countless people.
Therefore, in recent years, scientists have turned their attention to exploring the field of skin repair by regenerative medicine. Studies mainly focus on stem cell exosomes show that stem cell exosomes can play an important role in the treatment of skin diseases such as chloasma.
stem cell exosomes, how to solve chloasma from the source?
stem cell exosomes are tiny vesicles that can be secreted by most stem cells and . Once the exosomes are released from stem cells through exocytosis, complex mixed factors can be transmitted to other cells as signal molecules, thereby changing the functions of other cells.
For example, exosomes are like "messengers" that convey information, which can shuttle between various cells, such as keratinocytes, fibroblasts , endothelial cells , fat cells and immune cells . By passing information, it is to regulate and change the function of the cell. Research in recent years has shown that exosomes are also valuable candidates with regeneration and reconstruction potential. Exogenous exosomes produced by -induced pluripotent stem cells and umbilical cord mesenchymal stem cells show impressive and excellent characteristics, and can effectively repair skin problems. To some extent, exosomes derived from specific skin tissue cells or stem cells can not only treat various skin abnormalities, but also actively regulate skin homeostasis.
(Stein cell exosomes are widely distributed in the human body)
Some time ago, a review published in the international journal Regen Ther reviewed the report on regenerative medicine in clinical applications in recent years in Japan. The report mentioned stem cell exosomes and pointed out that stem cell exosomes can be used to reduce facial wrinkles, improve skin roughness, dryness and sagging, and can also be used for the treatment of pigmentation lesions, including the treatment of chloasma, age spots, vitiligo, etc.
Nowadays, many stem cell exosomes have been used in the treatment of stubborn melasma. For example, in the following case, Ms. Wu, 47, has more chloasma on her face and has darker color. She has undergone several photoelectric therapy treatments and has also used drugs such as azelaic acid , but the effect is not significant. So Ms. Wu decided to receive stem cell exosome treatment. After confirming that Ms. Wu's current melasma is in a stable period, she underwent comprehensive treatment of stem cell exosomes combined with photoelectricity. After three months of treatment, it was seen that the chloasma on her face had basically disappeared, and the skin wrinkles were reduced, and the skin condition had significantly improved. She has not recurred for August after the follow-up.
. In another case of melasma patients, Ms. Zhou, 29, has an active chloasma on her face and needs to reduce surface stimulation. Therefore, deep irrigation is adopted and stem cell exosome treatment is used. After two treatments, it can be seen that her chloasma has basically disappeared. It is recommended that she continue to consolidate and treat her for a period of time to reduce the chance of recurrence of melasma.
exosomes act as "messenger" between cells, and more and more studies have shown their potential in skin repair and regeneration.It is worth noting that stem cell exosomes are used for the treatment of skin problems such as chloasma, and plans are also required to be formulated based on individual skin conditions. For example, dosage and frequency of administration must be individualized to achieve the maximum improvement effect.
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