引言
作为细胞进行有氧呼吸和能量生产的主要场所，线粒体（mitochondria）是一种几乎存在于所有真核细胞中的细胞器，被称作细胞的“动力工厂”。近年来研究发现除了为细胞基本生命活动提供能量，线粒体还在细胞信号转导、代谢产物合成、基因转录调控和细胞凋亡等过程中扮演重要角色【1,2】。以上线粒体功能的研究主要在单细胞真核生物（例如酵母）或体外培养细胞系中完成，对于其在高等生物体内细胞增殖、分化和命运决定过程中的功能性研究还十分有限。此外，在多细胞构成的组织与器官水平下，线粒体损伤导致的细胞胁迫对于不同类型细胞生命活动的影响是否具有偏好性仍是一个有待解决的问题。
2024年8月23日，加州大学圣地亚哥分校孙欣实验室在cell stem cell杂志在线发表了题为“context-dependent roles of mitochondrial lonp1 in orchestrating the balance between airway progenitor versus progeny cells”的研究论文。该研究揭示了线粒体在呼吸道上皮组织发育、稳态维持以及损伤修复中的功能，并且发现线粒体在同一组织中以细胞特异性的方式调控细胞增殖分化、凋亡或者长距离迁移。
参考文献
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