Introduction: "New coronavirus-like" unexplained pneumonia has caused many deaths; the risk of sudden death can be predicted in advance through genetic scores; human eggs have been dormant for 50 years and still have the ability to reproduce ... Bioexploration will pay attention to "drug" news with you, Discover the value of biotechnology!
01 "Similar to new coronavirus " Unknown
pneumonia has caused many deaths
Recently, Argentina reported a mysterious pneumonia case similar to the new coronavirus. At present, 6 people in the country have been infected with this "pneumonia of unknown cause", and 3 people have died due to the disease. It is understood that among the nine infected people, eight are health workers and one is a severely ill patient receiving treatment at a private clinic in Tucumán Province, Argentina.
Ruiz, the head of the Tucuman provincial health department, said on Wednesday that the test results of these patients were negative for more than 30 viruses including COVID-19, influenza, . These infected people all suffered from severe respiratory diseases, accompanied by bilateral pneumonia, with symptoms very similar to those of COVID-19.
It is reported that samples of this unknown virus have been sent to institutions such as the Malbran Institute in Buenos Aires and the National Health Laboratory of Argentina for testing. At the same time, the European Center for Disease Control and the World Health Organization (WHO) also began investigating the virus.
02 Risk of sudden death can be predicted in advance by
genetic score
8 30, CE Dars-Sinai Medical Center Smidt Heart Institute research team published in Journal of the American College of Cardiology A new study shows that a polygenic risk score can effectively identify Risk of sudden cardiac death.
A heart attack (myocardial infarction) is usually caused by a blockage in the coronary arteries that reduces blood flow to the heart muscle. The most common cause of sudden cardiac death is a sudden onset of erratic electrical activity that impairs the heart's pumping function. Patients are asymptomatic or have few symptoms before the onset of the disease. If cardiac resuscitation is not performed on the patient, sudden cardiac death usually results in death within minutes.
The study showed that patients with coronary artery disease who did not have severe impairment of heart function had the highest polygenic risk scores, meaning they had a 77% increased risk of sudden cardiac death. There is an opportunity to identify patients at the highest risk of sudden cardiac death and then provide meaningful preventive treatment solutions that can effectively avoid sudden cardiac death.
03 Human eggs have been dormant for 50 years
Still have the ability to reproduce
Recently, an article published by Nature showed that human egg cells can change their metabolic activity, which allows them to maintain their ability to reproduce for up to 50 years. Human eggs first form in the ovary, but during the early stages of their maturation process, immature egg cells called oocytes are in a state of cellular arrest, dormant in the ovary for up to 50 years.
Like all other eukaryotic cells , oocytes also have mitochondria that power the cell, producing energy to meet the needs of the cell during dormancy, a process that is the same as standby mode. Immature human egg cells skip basic metabolic reactions critical for energy production to avoid the production of reactive oxygen species, harmful molecules that can accumulate, damage DNA and cause cell death.
A complex of proteins and enzymes called Complex I is the cell's "gatekeeper," initiating the reactions needed to produce energy in mitochondria; mitochondria are the most basic organelles of living organisms , but they are almost invisible in oocytes. Doesn't exist. This finding explains why some women but a quarter of women with the mitochondrial disease associated with other mitochondrial respiratory complex diseases have no reduced fertility compared with women with other mitochondrial respiratory complex diseases. Cases of female infertility remain unexplained.
04 BGI's thalassemia gene detection kit
gene detection kit was approved
Recently, BGI's thalassemia gene detection kit (combination probe-anchored synthesis sequencing method) was approved by CE-IVDD. The detection kit is developed based on the next-generation sequencing (NGS) technology combined probe-anchored synthetic sequencing method and is used for the qualitative detection of α-thalassemia and β-thalassemia mutations.Peripheral blood samples will be used for genetic screening of the general population for alpha or beta thalassemia mutations and for diagnosis of patients and suspected patients with these mutations as well as dyshemoglobinopathies.
05 New regulations for online sales of drugs are released
Online sales of prescription drugs are subject to a real-name system
html On September 1, the State Administration for Market Regulation issued the " Drug Online Sales Supervision and Management Measures " (referred to as the "Administration Measures"), which will take effect from December 1, 2022 Implementation. The "Management Measures" clarify the management of online sales of prescription drugs and consolidate the responsibilities of drug online sales platforms."Management Measures" points out that taking into account medication safety risks and online and offline consistency management requirements, it is clear that online sales of prescription drugs shall be subject to a real-name system, and prescriptions shall be reviewed and distributed in accordance with regulations; prescription drugs and non-prescription drugs shall be displayed separately and clearly listed on the prescription drug sales homepage. Information such as packaging and labels must not be directly publicly displayed on the front page or homepage; information such as instructions must not be displayed before the prescription is reviewed, and services related to the purchase of prescription drugs must not be provided. This is intended to emphasize the management requirements of "prescription before medicine" and prescription review. At the same time, it is required that before selling prescription drugs, relevant risk warning information should be fully informed to consumers and consumers should confirm their knowledge, so as to effectively prevent drug safety risks.
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