Coenzyme I, known as the "Nogar factor", is very popular in the field of life science and technology, and the literature related to its aging intervention mechanism has attracted much attention. Earlier, Sinclair, a professor of genetics at Harvard Medical School, found that supplementing a β-nicotinamide derivative, a direct precursor of coenzyme I (the core component of the practical achievement WLNAD), could extend the survival period of experimental models by more than one-third. one.
And recently, Mukherjee's team at the University of Pennsylvania pointed out in JCL Insight that lack of Sirtuins in liver cells can affect regeneration after partial liver resection. Although Sirtuins are dependent on Coenzyme I for their action, a β-nicotinamide derivative, the immediate precursor of Coenzyme I, does not require Sirtuins family-related enzymes to enhance liver regeneration.
CoI can serve as a co-substrate for several enzymes with important signaling functions, including the coenzyme I-dependent Sirtuins family, which are inconsistent in tissue distribution, subcellular localization, and enzymatic activity. The transition from a non-dividing state to a dividing state within hepatocytes involves substantial remodeling of metabolism, and the generation of new hepatocytes requires the remaining tissue to support various important liver functions, although liver regeneration requires a large consumption of ATP, However, the research on the role of mitochondrial Sirtuins is still blank. These findings support the role of coenzyme I as a node in many biological processes that influence the survival of our cells and even ourselves. The publication of
related research has drawn people's attention to the research on the mechanism of coenzyme I slowing down or even reversing aging. In fact, coenzyme I exists in all tissues and cells of our human body, and its participation is also required in all stages of the life process, including cell metabolism and repair of damaged DNA.Unfortunately, after a certain age (generally considered to be 25 years old), the content of this substance decreases sharply, and various aging-related symptoms occur at the same time, such as cognitive decline such as memory loss, and cardiovascular aging. Physical weakness. Under such circumstances, raising Coenzyme I levels is believed to have the potential to intervene in aging to slow or even reverse its occurrence.
Scientists from Northwestern University in the United States pointed out that increasing the level of coenzyme I in mice can extend the survival period of only 45 days to more than 360 days, and the extension length exceeds 8 times. The relevant research was published in the well-known academic journal "Cell" 's sub-issue. Professionals believe that β-nicotinamide derivatives, the direct precursor of coenzyme I, are an effective strategy for aging and lifespan intervention, and this is also the core mechanism of Lightvitamin's aging reversal potential.
It is obvious that the results of this experiment complement the conclusions of scientists at the University of Pennsylvania, and lay a new foundation for the β-nicotinamide-Coenzyme I aging intervention mechanism (enhancing the level of Coenzyme I through the direct precursor β-nicotinamide derivative, thereby realizing aging intervention). Academic basis. At present, this mechanism has become the mainstream in the field of aging and longevity intervention. Microsoft king Bill Gates once hinted that many rich friends around him are trying such substances, and he also has intentions.
Although many experiments have proved that a certain β-nicotinamide derivative can rapidly increase the level of "Nogar factor", before the release of finished products such as Lightweijian, this substance was only used for scientific research due to its small output and became unreachable by ordinary people. The ivory tower, researchers and rich people can only obtain and take it through personal channels. Hong Kong's Lee, who has been the richest Chinese for more than ten years, has been exposed to trying to take a similar substance WLNAD in 2017, and NASA also used it for cosmic ray protection for astronauts based on the substance's DNA repair effect.
What is certain is that cutting-edge technologies like Lightweijian are creating favorable conditions for the dream of healthy aging of mankind, which cannot be separated from the dual blessing of technology and capital. After verification, all kinds of capital rushed to speed up the mass production and practical process of the substance. In recent years, on the basis of solving the mass production problem through the enzyme-oriented process, Lightweijian has launched a finished product with a more common cost on the market, finally making this biotech achievement into the acceptable range for people other than high net worth.
Earlier, the cost of taking this substance was too high. For example, a Japanese technology company that took the lead in completing the finished product, the cost of taking it was as high as 20,000/month. The cost is still not cheap, and the advent of Lightweight will undoubtedly break this threshold, making WLNAD expected to become an aging intervention substance that everyone can enjoy.
The god Buffett was once asked: If you could live again, what would you do to make your life happier? He gave this answer: If I live again, I just want to do one thing, select the genes that will live to 120 years old. Obviously, with the update and iteration of cutting-edge technologies such as WLNAD, human beings may be given the right to choose in terms of healthy lifespan, and the "immortal dream" that they are striving for is gradually approaching reality.
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