Although people of different regions or races intestinal bacteria genus roughly similar to , but the types of strains enriched by are very different. Where does the differences in this strain type come from? How to associate with its host? (1)
Researchers such as Ruth E. Ley from the Max and Max Institute of Germany answered this question. By simultaneously analyzing the 1225 cases of human genome and its 59 intestinal bacteria , which have intestinal bacteria (phylogenetic tree analysis) , the researchers found that more than 560% of in intestinal bacteria have parallel evolution paths with their host. Further, the researchers found that bacteria with high parallelism with the host evolution path showed characteristics of adapting to "parasitics", such as reduced genome, high proportion of essential genes, and more sensitive to oxygen concentration and temperature; while bacteria with low parallelism with low evolution of showed characteristics similar to bacteria that live freely outside the world (1).
sample source and parallel evolution of the host genome with some intestinal bacteria (1) Bacteria with high parallelism with host evolution (large PACo effect size) show "parasitic" characteristics (1)
This work was published in Science on September 15, 2022; researchers said that this work updated everyone's understanding of the interaction between intestinal microbiota and host, indicating that population characteristics need to be considered for treatment based on flora (1, 2).
Comment(s):
Looking forward to the more systematic and comprehensive analysis of intestinal microbiota with the advancement of technology, will analyze in a more systematic and comprehensive manner on the intestinal microbiota (it is currently difficult to analyze rare and difficult to cultivate microbiota), so that will be more systematic and systematic and will understand the co-evolution of bacteria and hosts, their functions and therapeutic effects.
References:
1. T. A. Suzuki et al., Codiversification of gut microbiota with humans. Science (80-. ). 377, 1328–1332 (2022).
2. Gut microbes and humans on a joint evolutionary journey | Max-Planck-Gesellschaft, (available at https://www.mpg.de/19222205/0915-entw-gut-microbes-and-humans-on-a-joint-evolutionary-journey-151730-x).
Original link:
https://www.science.org/doi/10.1126/science.abm7759
