One of them is a monovalent vaccine and the other is a bivalent vaccine. A total of 1,234 people over the age of 56 were enrolled in the Phase II/III studies of these two Omicron vaccines. It was found that as a booster vaccination, compared with the new coronavirus vaccine devel

2024/04/1713:24:33 science 1200

On June 25, Pfizer/BioNTech announced that the two new crown vaccines developed in cooperation against the Omicron variant showed positive safety, tolerability and immunogenicity results in clinical trials. One of them is a monovalent vaccine and the other is a bivalent vaccine.

The two Omicron vaccines (30 μg and 60 μg) enrolled a total of 1,234 people over the age of 56 in the Phase II/III study. It was found that as a booster vaccination, compared with the new coronavirus vaccine developed by the company in 2019, it was more effective against Omicron BA. 1 variant strains can produce strong neutralizing antibody levels. The preset efficacy standard of the study was based on the neutralizing antibody geometric mean titer ratio (GMR). The results showed that the GMRs of the monovalent vaccine 30μg and 60μg were 2.23 (95% CI: 1.65, 3.00) and 3.15 (95%) respectively. CI: 2.38, 4.16). The GMRs of 30 μg and 60 μg bivalent vaccines were 1.56 (95% CI: 1.17, 2.08) and 1.97 (95% CI: 1.45, 2.68) respectively. The above-mentioned efficacy and safety results of the variant-adapted vaccine against Omic are in compliance with the regulatory requirements for emergency use authorization by regulatory agencies. One month after

vaccination, one dose of monovalent Omicron vaccine (30 μg and 60 μg) as a booster immunization can increase the neutralizing antibody geometric mean titer (GMT) by 13.5 and 19.6 times respectively compared with before the boost. Injection of one dose of bivalent Omicron vaccine (30 μg and 60 μg) increased GMT by 9.1 and 10.9 times, respectively. Both vaccines were well tolerated by people who had received other Omicron vaccines.

When conducting a SARS-CoV-2 live virus neutralization test on the subject's serum, it was found that the titer of the neutralized serum BA.4/5 was approximately 3 times lower than that of BA.1. Pfizer/BioNTech will continue to collect additional trial data against the Omicron BA.4/5 variant in the coming weeks.

Pfizer/BioNTech plans to discuss the above data with the FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) and the EMA International Alliance of Medicines Regulators (ICMRA) on June 28 and June 30 respectively. The companies have submitted additional data to regulators on their existing COVID-19 vaccine, Comirnaty, as a booster shot.

science

Star: It means the sky is full of stars, and the Hehan constellation is called a star. Dou: mostly refers to Beidou and South Dou. Also includes East Dou, West Dou, and Middle Dou. There is a Star Lord among the stars, who rules over the stars. The stars are bright, and the ancie - DayDayNews

Star: It means the sky is full of stars, and the Hehan constellation is called a star. Dou: mostly refers to Beidou and South Dou. Also includes East Dou, West Dou, and Middle Dou. There is a Star Lord among the stars, who rules over the stars. The stars are bright, and the ancie

Welcome to the North Pole and Beidou’s descent | Did you know that Beidou actually has “nine stars”?

05/06 1289

To understand Chinese animals, Chinese people need to read popular science books written by the Chinese themselves. "My Wild Animal Neighbors" is interesting, story-based, and scientific, and is suitable for people of all ages. - DayDayNews

To understand Chinese animals, Chinese people need to read popular science books written by the Chinese themselves. "My Wild Animal Neighbors" is interesting, story-based, and scientific, and is suitable for people of all ages.

It's a peacock, it's a peacock, they're different peacocks

05/06 1059

Researchers such as Ma Qiufu of Harvard Medical School recently published a Nature article and found that a sensory nerve deeply enriched in the corresponding position of "Zusanli" in mice mediates this process through the vagus nerve-adrenal axis. - DayDayNews

Researchers such as Ma Qiufu of Harvard Medical School recently published a Nature article and found that a sensory nerve deeply enriched in the corresponding position of "Zusanli" in mice mediates this process through the vagus nerve-adrenal axis.

Nature | The "structural basis" for the specific function of "acupoints"

05/06 1946

The passage of laser pulses through non-uniform media is the most important process, and the control ability determines the efficiency of optical communication. Unfortunately, it is often impossible to model it mathematically. However, you can teach a neural network to predict it - DayDayNews

The passage of laser pulses through non-uniform media is the most important process, and the control ability determines the efficiency of optical communication. Unfortunately, it is often impossible to model it mathematically. However, you can teach a neural network to predict it

Neural network predicts behavior of laser pulses

05/05 1393

Massive planets can retain atmospheres and water for long periods of time if they are fairly far away from their stars. If they were driven out of their mother lineage, it would last longer than the existence of the universe. Conditions on Earth became suitable for life billions - DayDayNews

Massive planets can retain atmospheres and water for long periods of time if they are fairly far away from their stars. If they were driven out of their mother lineage, it would last longer than the existence of the universe. Conditions on Earth became suitable for life billions

Super-Earths may still be habitable for tens of billions of years

05/05 1953

On June 29, citizens in Guiyang, Guizhou Province took photos of a "UFO" appearing in the sky. According to citizens' descriptions, the flying object was like a rocket launching with a long tail, flying from the ground to space, and the flight duration was about 2 Minutes later, - DayDayNews

On June 29, citizens in Guiyang, Guizhou Province took photos of a "UFO" appearing in the sky. According to citizens' descriptions, the flying object was like a rocket launching with a long tail, flying from the ground to space, and the flight duration was about 2 Minutes later,

UFO? A "UFO" appeared in the sky over Guizhou and flew for 2 minutes. What is it?

05/05 1679

Wang Jianping: One article per day: "Theory of Perception." Part 9" (98) Why are there differences among people? According to general logical inference, the reason why human society can be formed and operated is based on the commonality of people. Human society is a collection of - DayDayNews

Wang Jianping: One article per day: "Theory of Perception." Part 9" (98) Why are there differences among people? According to general logical inference, the reason why human society can be formed and operated is based on the commonality of people. Human society is a collection of

Great things are happening in the world: Can a harmonious world be realized?

05/05 1630

Is the universe finite or infinite? This issue has been debated for a long time. Some people think that the universe has a boundary, because the maximum boundary that the Hubble Telescope can see is about 92 billion light-years, which should be the limit of the universe. However, - DayDayNews

Is the universe finite or infinite? This issue has been debated for a long time. Some people think that the universe has a boundary, because the maximum boundary that the Hubble Telescope can see is about 92 billion light-years, which should be the limit of the universe. However,

Are there boundaries to the universe? After continuously enlarging it, you will find that the structure of the universe is similar to the structure of life

05/05 1284

The earth contains huge energy, but humans are only using the energy on its surface. Most of the energy used by humans is fossil energy, which was obtained by ancient organisms after a series of changes. It is essentially the energy on the surface of the earth's crust. However, m - DayDayNews

The earth contains huge energy, but humans are only using the energy on its surface. Most of the energy used by humans is fossil energy, which was obtained by ancient organisms after a series of changes. It is essentially the energy on the surface of the earth's crust. However, m

Drill 20 kilometers into the earth’s crust! Unleashing unlimited energy, what exactly is the technology of the American company’s wave drill?

05/05 1073

The reason for foreign netizens is that objects should be weightless in space. However, when teaching in space on the Chinese Space Station, the water is still the same as on the ground. It is stable in the water cup and does not float out. Some foreign netizens even launched con - DayDayNews

The reason for foreign netizens is that objects should be weightless in space. However, when teaching in space on the Chinese Space Station, the water is still the same as on the ground. It is stable in the water cup and does not float out. Some foreign netizens even launched con

China's space lecture was questioned because it was shot on the ground because of "a glass of water". Are foreigners upset?

05/05 1560