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FDA drug pregnancy C grade, which means that this drug has adverse effects on the fetus (teratogenic or cause embryo death or other) by animal experiments, but there are no female controlled studies, or there are no female or animal studies available. This type of drug can only be used after weighing the benefits to pregnant women outweigh the harm to the fetus.
ciprofloxacin is a "C-grade drug". It is a synthetic third-generation quinolones antibacterial drug. It has broad-spectrum antibacterial activity and good bactericidal effect. It has antibacterial effects on Enterobacter , Pseudomonas aeruginosa , Haemophilus influenzae , Gonococci , Streptococcus , Legionella , Staphylococcus aureus .
So, what should I pay attention to when taking medication during pregnancy and breastfeeding? What impact will it have?
Can it be used during pregnancy?
▎FDA grade: C-grade
According to published information available in case reports, case-control studies and observational studies of ciprofloxacin administration during pregnancy, in the long-term experience of ciprofloxacin used in pregnant women over the past few decades, has not found any significant birth defects, miscarriages or adverse maternal or fetal outcome risks associated with any drug in .
ciprofloxacin was administered orally to pregnant mice and rats during the organ formation period, with a dose of up to 100 mg/kg, and ciprofloxacin was administered orally to pregnant rabbits, with a dose of up to 30 mg/kg, with a dose of up to not causing fetal deformity . These doses are up to 0.3, 0.6 and 0.4 times the maximum clinically recommended oral doses in mice, rats and rabbits, respectively (based on body surface area).
Can it be used during breastfeeding?
▎ Dr. Hale Lactation Grade: L3
Published Literature Report Ciprofloxacin is present in human milk after intravenous and oral administration.
has no information on the effects of ciprofloxacin on milk production or breastfeeding infants. Because breastfed babies have the potential risk of serious adverse reactions, including arthrosis shown in juvenile animal studies, for most indications, lactating women may consider aspiration and discarding milk during ciprofloxacin treatment and 2 days after the last administration. Alternatively, it is recommended that women do not breastfeed (5 half-life) during ciprofloxacin treatment and 2 days after the last administration.
However, for inhaled anthrax (after exposure), the risk of continuing breastfeeding during the event leading to exposure to anthrax, mothers (and potential infants) are receiving ciprofloxacin treatment-benefit assessment may be acceptable.
should consider the developmental and health benefits of breastfeeding, as well as the mother’s clinical need for ciprofloxacin and any potential adverse effects of ciprofloxacin or maternal underlying disease on breastfed infants.
ciprofloxacin may cause changes in intestinal flora in breastfeeding babies. It is recommended that women monitor whether breastfed babies have loose or bloody stools and candidiasis (thrush, diaper rash).
Where can I check the information on pregnancy/lactation medication?
Which drugs cannot be encountered during pregnancy? Which drugs can be secreted through milk? When prescribing medicines in obstetrics and gynecology, you must be very cautious!
What will the impact on the fetus if the doctor prescribes this medicine for me? Will this symptom be caused by the drug?
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Reference:
[1]Product Information: CIPROFLOXACIN-ciprofloxacin hydrochloride tablet, film coated, Aurobindo Pharma Limited, Updated January, 2022.
[2]Product Information: CIPROFLOXACIN-ciprofloxacin hydrochloride tablet, film coated, Chartwell RX, LLC., Updated April, 2022.
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