For diabetes patients, he is very familiar with metformin . Most diabetic patients go to the hospital to see a doctor, and the doctor will prescribe metformin. Moreover, metformin has been around for about half a century since its birth. During this period, he also defeated his brother benzedformin and became the first-line drug for the treatment of type 2 diabetes.
Why do doctors like to prescribe metformin?
metformin is a "authoritative" drug for treating html type 12 diabetes . It is listed as a first-line anti-glycemic drug among a variety of treatment guidelines at home and abroad.
metformin has the advantages of having the exact effect of lowering glycemic, low risk of hypoglycemia, and low price. It is one of the most widely used Class A hypoglycemia drugs.
1. Metformin Butdan is suitable for type 2 diabetes. Even if metformin is used in patients with type 1 diabetes, it can reduce the dosage of insulin to help control blood sugar.
2. Metformin can not only effectively reduce blood sugar and glycated hemoglobin . Currently, clinical studies have shown that long-term use of metformin can also reduce the risk of cardiovascular disease in diabetics. helps to improve the blood lipid spectrum of patients with dyslipidemia and , and has an improvement effect on non-alcoholic fatty liver patients and polycystic ovary syndrome patients.
3. Metformin is also widely used. Children over 310 years old and elderly people over 80 years old can take under reasonable monitoring of liver and kidney function.
4, metformin can also be used in combination with and other hypoglycemic drugs.
5. Metformin does not harm the liver and kidneys. Metformin does not undergo liver metabolism, and does not compete with the liver's P450 enzyme . Therefore, it has no effect on the liver. However, for those with severe liver insufficiency, it should be prohibited to take metformin to avoid adverse reactions from acidosis.
metformin is in the form of its original form, excreted from the kidney through the urine, and has no adverse effects on the kidneys. However, if the glomerular filtration is too low than 30, metformin cannot be taken.
Can metformin be taken as a hypoglycemic drug for a long time? Can the kidneys afford it?
Because metformin is excreted through the kidneys, many people are worried that taking metformin for a long time will affect the kidneys. In fact, metformin does not have direct damage to the kidneys, but will cause drugs to accumulate in the body of patients who already suffer from liver diseases.
Since metformin is not metabolized by the liver organs, it does not degrade in the body mainly by prototype excretion through the kidneys. Patients who take metformin need to frequently check liver and kidney function.
Patients with poor liver and kidney function should not take metformin. is to avoid the accumulation of metformin drugs to induce lactic acidosis, , especially chronic obstructive pulmonary disease, severe heart failure, and other hypoxia, the degradation of glucose anaerobic sugar in patients increases, and is prone to lactic acidosis.
If metformin alone is taken for more than three months and has reached the best or maximum dose, but blood sugar is still not controlled within a reasonable range. can take some other hypoglycemic drugs on the basis of metformin.
Although metformin can bring a very obvious hypoglycemic effect, many patients still cannot tolerate the adverse reactions brought by metformin, and some small number of patients cannot take them for a long time due to adverse reactions.
What side effects will long-term take on metformin bring to the body?
harms the stomach and intestines
Some diabetic patients will experience various discomfort when taking metformin, The stomach and intestines , such as diarrhea, abdominal distension, no appetite, and weight will also decrease accordingly.
causes anemia
Taking metformin for a long time can affect the intestinal uptake and absorption of vitamin B12. over time will lead to megacellular anemia , which will cause dizziness and prone to illness.
What should I pay attention to during taking metformin?
Precaution to use the dose of medication
When taking metformin, should start with a small dose of , take it once every morning and evening, and arrange one tablet for each medication after meals. This can improve the safety of medication, improve the body's tolerance, and reduce adverse drug reactions.
Pay attention to the combination medication
If you take metformin alone to control the blood sugar, you can use the medication in combination if it is not ideal. Metformin has very high compatibility and can be taken with many drugs. However, when choosing a combination medication, you should monitor your blood sugar level regularly to prevent the inducing hypoglycemia.
Regularly monitor liver and kidney function
Patients who take metformin for a long time should regularly monitor their liver and kidney function to see if the drug causes damage to the liver and kidneys, especially for severe liver insufficiency glomerular filtration rate , less than 30 ml, may experience acidosis after taking metformin for a long time, so be sure to pay attention.
Reasonable supplement of vitamin B12
Since metformin will affect the intestinal absorption of vitamin B12, long-term medication should be taken to reasonably supplement vitamin B12. Vitamin B12 can be obtained from seafood, lean meat, animal offal, fish, green leafy vegetables, and soy products, and can also be directly supplemented with vitamin B12 tablets.
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