In March 2022, Professor Chen Youxin 's team of Professors of Ophthalmology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences published a case image titled "Retinopathy in an Older Adult Man With Waldenström Macroglobulinemia" in the journal JAMA Ophthalmology. This case was a rare patient with Waldenström macroglobulinemia, and its ultra-wide-angle fluorescein angiography images reflect the retinal manifestations of hyperviscosity in both eyes.
Figure: Waldenström Ultra-wide-angle fluorescein angiography of retinopathy
This patient was a Waldenström macroglobulinemia patient diagnosed and treated in our hospital. Due to his vision decline, fundus fluoresceinography showed the tortuosity of the retinal vessels in the patient's eyes and showed a "sausage chain-like" appearance. Retinal blood vessel leakage, ischemia and other symptoms can be seen around.
It is understood that Waldenström macroglobulinemia is a class of inert non-Hodgkin lymphoma characterized by the proliferation and infiltration of bone marrow lymphatic plasma cells and the secretion of M-type monoclonal immunoglobulin (IgM). This disease was first reported by Jan Gosta Waldenström in 1944. The incidence rate of this disease is extremely low, with an annual incidence rate of about 3 cases per million. Waldenström macroglobulinemia retinopathy is a clinical manifestation of hyperviscosity caused by this disease. Patients may experience decreased vision and deformed vision. Fundus examination can find that retinal vascular segmental tortuous dilation of retinal vessels in this type of patient, accompanied by extensive bleeding, exudation and disc edema, and central retinal vein occlusion . Therefore, patients with Waldenström macroglobulinemia should actively undergo fundus examinations during the course of the disease and diagnose and treat the disease in a timely manner.
[Author Information]
First author
Wang Yuelin, a doctoral student in Peking Union Medical College Hospital 2021 class, studied under Professor Chen Youxin. As the first author/co-first author, he has published many academic papers in journals such as Diabetes Metab Res Rev, JAMA Ophthalmol, Retina, and Chinese Ophthalmology Journal.
Corresponding author
Chen Youxin, chief physician, professor, postdoctoral supervisor, director of ophthalmology at Peking Union Medical College Hospital, and director of the Key Laboratory of Fundus Disease, Chinese Academy of Medical Sciences. Member of the Standing Committee of the Ophthalmology Branch of the Chinese Medical Association, former vice president of the Eye Physicians Branch of the Chinese Medical Association, president of the Ophthalmology Branch of the Beijing Medical Association, director of the Cross-Strait Medical and Health Exchange Association, deputy chairman of the Ophthalmology Branch and leader of the macular group, president of the Eye Health Branch of the China Elderly Health Association, deputy chairman of the Eye Microcirculation Professional Committee of the Chinese Microcirculation Society, etc. In recent years, we have focused on the application of PCV and ophthalmic artificial intelligence. Lead or collaborate in writing a number of academic papers published in magazines such as PRER, Lancet, Ophthalmology, JAMA Ophthalmology, AJO and BJO.
text/Wang Yuelin
editing/Cao Miao
rotating editor/Chen Di
editor/Zhao Chan
supervisor/Chen Youxin
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