"Expert Consensus on Preservation of Male Fertility in China" points out: In the past nearly half a century, male reproductive ability has decreased by nearly 50% . Unhealthy living habits guided by the business society have caused some young people who should be in the peak of reproduction to have "aging" sperm that does not match their biological age.
Age is an important determinant of human fertility, and the incidence of infertility also increases with the increase of age for pregnancy. But in addition to the "age shown on the ID card" we are familiar with, there is also a "sperm physiological age" that is more related to male fertility. The biological age of
cells is not the same as that of physiological age. The internal (such as genetic) and external (such as environmental, living habits) factors accumulated during life can have an impact on physiological age . According to Oxford University research, human spermatogonia splits every 16 days. In a man's life, spermatogonia will undergo about 1,400 divisions during their reproductive life (based on the average lifespan and count from adolescence). During this process, gene methylation errors (intergenic and gene regions) may continue to accumulate, resulting in sperm damage.
Another study showed that male sperm physiological age status is crucial to the success of conception. and without changing the genetic material DNA, the parents can even pass on certain acquired traits to the next generation through the epigenetic of . Herbal environmental exposures such as poisons, dietary nutritional abnormalities, or stress can promote epigenetic transgenerational genetic and phenotypic variation of the disease. These environmental factors can induce epigenetic reprogramming of the germline (sperm and egg).
With the development of epigenetic research, people have gradually realized that factors such as living and eating habits and environmental factors can regulate gene expression by affecting DNA methylation or histone modification. For the health of individuals and the next generation, men need to adjust their lifestyle during pregnancy preparation to keep the individual male sperm physiological age younger, and avoid passing on adverse effects to children .
1. Environmental pollution cannot be underestimated.
Environmental factors are important factors affecting the physiological age of male sperm . Environmental factors change the microRNA of sperm, DNA methylation or histone modification is passed on to offspring through fertilization, regulating the gene expression of offspring, affecting their phenotype, and thus producing During the reproduction process, the species population produces a cross-multiple response to the environment and may form an active evolutionary pattern
2. Living habits need to be strictly constrained
In terms of dietary habits, the early stage diabetes will change the methylation map of sperm and pass it to offspring to a certain extent, causing glucose tolerance and insulin resistance to offspring. In addition to diet, it is a consensus that DNA damage caused by smoking, drinking and staying up late and the physical benefits brought by exercise . Men who are preparing for pregnancy should try to restrain bad behaviors and exercise more.
3. Mental status needs to be adjusted
. In psychological aspects, such as fear, emotions, mental trauma, environmental stress and other environmental factors, they will also have epigenetic effects on sperm, and genetically affect the fear behavior of offspring and sugar metabolism . Therefore, men who are preparing for pregnancy should relax and pay attention to adjusting their psychological conditions.
4, appropriate supplements for dietary supplements
zinc and folic acid are often used for male infertility combined supplemental drugs . The concentration of zinc in the semen plasma is 30 times higher than in serum. Folic acid deficiency can change the methylation status of sperm genome. Folic acid not only provides a methyl donor for DNA methylation, but also helps to eliminate oxygen free radicals. However, to play the greatest role, folic acid also needs appropriate zinc combination with .
Men's fertility not only depends on the "ID card age", but also requires the support of the "physiological age" of sperm. Good sperm status is not only conducive to rapid conception, but also lays a solid foundation for your next generation!
This article is The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Reproductive Center Jiang Ping Deputy Chief Physician Reprinted and compiled on " Medical Obstetrics and Gynecology Channel " public account popular science article , thank you very much!
Anhui Provincial Hospital of Traditional Chinese Medicine Special diagnosis and treatment of Reproductive Medicine Center (Male Reproductive Zone):
Special diagnosis and treatment of leuko-aspermia: Department has a "Ligus and Aspermia Disease Clinic", " Male Fertility Assessment and Pregnancy Promotion Clinic", adopts "sperm activation technology" to effectively improve the pregnancy rate ; Premature Ejaculation integrated special diagnosis and treatment: Chinese and Western medicine combined with acupuncture and sperm control therapy to effectively control sexual life time ; Comprehensive diagnosis and treatment of erectile dysfunction: focuses on physical conditioning, with Chinese medicine as the main focus, Western medicine impact, and specimens are treated together ; Prostate special diagnosis and treatment: focuses on overall pelvic conditioning, highlighting the characteristics of Chinese medicine; fetal discontinuation diagnosis and treatment of Chinese medicine: carries out comprehensive etiology screening for fetal discontinuation, and implements traditional Chinese medicine special intervention treatment for fetal discontinuation for various reasons .
Our hospital consultation and appointment Official WeChat account - " Anhui Provincial Hospital of Traditional Chinese Medicine " - Reproductive Center.
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