On August 22, at the launch meeting of the Yttrium-90 microsphere interventional treatment of liver tumor project held in the Second Affiliated Hospital of Guangzhou Medical University, Zhu Kangshun, director of the minimally invasive interventional department of the hospital, in

2024/12/1623:11:32 regimen 1393

htmlOn August 22, at the launch meeting of the yttrium 90 microsphere interventional treatment of liver tumors project held at the Second Affiliated Hospital of Guangzhou Medical University, Zhu Kangshun, director of the minimally invasive interventional department of the hospital, introduced that in addition to the traditional "irrigation" and "blocking" In addition to the "burning" and "irradiation" methods, the hospital has also introduced a new "weapon" - yttrium 90 microsphere technology, hoping to provide new treatment options for more patients with liver cancer and colorectal cancer liver metastasis.

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Author: Jevin

Traditional treatments are not effective

Liver cancer is known as the "silent killer", including primary liver cancer and liver metastases. . At present, the early diagnosis rate of liver cancer in my country is low, and most patients are already in the middle and late stages when diagnosed. Liver metastasis is the most common type of colorectal cancer. About 50% of colorectal cancer patients will develop liver metastasis. Only 10% to 20% of these patients can be treated with surgery. The 5-year survival rate of patients who cannot be operated is Less than 5%.

Zhu Kangshun introduced that traditional liver cancer treatment methods include tumor vascular chemotherapy infusion ("irrigation"), tumor arterial chemoembolization ("blocking"), radiofrequency ablation and microwave ablation ("burning"), and radioactive seed implantation Four forms including technique ("photography"). Although they have been widely used in the treatment of early, intermediate and advanced liver cancer, the therapeutic effect is still insufficient.

Yttrium 90 microsphere technology

In February this year, yttrium 90 microsphere technology was officially approved for marketing, and the Second Hospital of Guangzhou Medical University became the first tertiary hospital in South China to implement this technology. Zhu Kangshun introduced that yttrium-90 microspheres are tiny spheres containing the radioactive isotope yttrium [90Y]. When treating liver cancer, interventional doctors will use microcatheters to inject the yttrium microspheres into the hepatic artery that supplies blood to the tumor. In the process, the microspheres follow the blood flow to the liver tumor site and break the DNA double strands by emitting high-energy β rays to kill the tumor.

"85% of patients have lost the opportunity for surgery because the tumor is too large or has metastasized remotely." Professor Xu Hao, director of the Medical Imaging Department of the First Affiliated Hospital of Jinan University and director of the Department of Nuclear Medicine, said, "Yttrium-90 treatment has the potential to emit radiation. Pure beta rays, with their high energy, short tissue penetration distance and good safety, are an effective option for patients with colorectal liver metastasis or primary liver cancer.”

"In vivo radiotherapy method kills tumors, which is more accurate, more effective and safer." Zhu Kangshun said that the killing ability of yttrium 90 microsphere technology on tumor tissue is much higher than that of external radiation therapy, and it causes less damage to normal tissue. It is currently suitable for patients with liver malignancies that are unresectable or unwilling to undergo surgical resection or ablation therapy. However, individual differences and economic costs need to be considered during treatment. Not everyone is suitable for this technology. According to public media reports, on March 18, 2022, the first liver cancer patient in China treated with Yttrium-90 Microsphere Injection was clinically cured after undergoing surgical treatment.

Application Prospects

Yttrium-90 therapy is currently mainly used in the downstaging and bridging surgical resection of liver metastases of colorectal cancer; palliative and salvage treatment of huge liver tumors to improve the quality of life; radioactive liver segment ablation, Treatment scenarios such as damage treatment. Overall, the objective response rate of liver cancer patients after applying this technology is significantly better than other treatment options. Its therapeutic effect on patients with advanced liver cancer is also reflected in a substantial improvement in median survival.

Dean of the Second Hospital of Guangzhou Medical University Xiao Guohong said that the hospital has always been at the leading level in South China in the treatment of liver cancer. The hospital has established a multidisciplinary liver tumor consultation team to formulate individualized treatment plans for patients. In the future, the hospital will vigorously promote the application of yttrium-90 projects and give full play to the technical advantages of key disciplines such as minimally invasive interventional surgery, nuclear medicine, hepatobiliary surgery, and gastrointestinal surgery to benefit more patients.

Reference:

https://c.m.163.com/news/a/HFFG7QQE055004XG.html

Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans. If you need health guidance, please go to a regular hospital.