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During the epidemic, not only masks were out of stock, but many antiviral drugs were also out of stock, such as the Shuanghuanglian , which was sold out, and not to mention the drugs for treating the new crown.
A few days ago, the fifth edition of the diagnosis and treatment plan for the new coronary pneumonia was announced, including ribavirin, a common medicine prescribed by pediatrics in many hospitals, and the manufacturer said it would increase production.
Increased production of drugs for treating COVID-19 was originally a good thing, after all, the most important and urgent thing now is to control the epidemic. But I’m afraid that many people will buy ribavirin on their own like they are rushing to grab Shuanghuanglian and antiviral drugs.
Don’t take medicine by yourself.
people who rush to shuanghuanglian have been hospitalized
Some time ago, news that "shuanghuanglian has an inhibitory effect on the new coronavirus" was reported, which triggered many people to scramble to buy. However, many people still get infected or worsened after taking Shuanghuanglian.
Maybe many people have ribavirin at home, or it is easy to buy it in pharmacies. Remind everyone, don’t buy or take it yourself.
First of all, it is really hard to say that the effect of buying medicine for taking it without the doctor's diagnosis and condition evaluation.
Secondly and most importantly, ribavirin is carcinogenic and teratogenic, and is not suitable for children, pregnant women and those who are preparing for pregnancy.
Image source: Visual China
Ribavirin is widely used in pediatrics
But it is not suitable for children at all
ribavirin, also known as virozole, is a broad-spectrum antiviral drug. The abuse of ribavirin to treat various viral infections is very common in our country.
Especially in pediatric prescriptions, ribavirin is widely used to treat common diseases such as colds, flu and hand, foot and mouth disease .
But ribavirin is very controversial in clinical use because this antiviral drug is also harmful to normal cells.
In the World Health Organization (WHO) drug adverse reaction database, there are more than 8,600 adverse reactions reported in ribavirin, involving more than 26,000 adverse reactions;
Among them, there are 126 adverse reactions that are abnormal fetal, 45 explicitly deformed, and deformed involving multiple systems;
adverse reactions are manifested as tumor ; 81 adverse reactions are manifested as tumor ; 123 adverse reactions are manifested as hemolytic anemia .
According to the recommendations of US Food and Drug Administration , ribavirin is only suitable for the treatment of hepatitis C, human respiratory fusion virus (RSV), and certain hemorrhagic fever (WHO).
In addition, FDA clearly states that ribavirin is not suitable for treating influenza.
If it is for the treatment of hand, foot and mouth disease, it should be limited to severe illness, and the doctor needs to determine whether to use it.
PS: If the doctor prescribes this medicine to the child, parents can consult other doctors or experts if they are not at ease.
Image source: Visual China
ribavirin, which was included in the fifth edition of the diagnosis and treatment plan for the new coronary pneumonia, has severe teratogenic effects, and pregnant mothers must be careful.
If you use ribavirin without knowing that you are pregnant, the result is likely to be a pity.
Pregnant women and pregnant women
need to be alert to ribavirin
Ribavirin is included in the fifth edition of the diagnosis and treatment plan:
According to the National Health Commission's "Diagnosis and Treatment Plan for Pneumonia Infected by the New Coronavirus Infection (Trial Fifth Edition)" issued by the National Health Commission on February 5, 2020:
New content for antiviral treatment "ribavirin may be added intravenous injection (500mg per adult, twice a day)."
However, use ribavirin to treat new coronavirus pneumonia, must strictly follow the doctor's instructions for medication.
In 2006, the CFDA's information on adverse drug reactions had been reported on the safety of ribavirin, indicating that ribavirin is not suitable for women of childbearing age, especially pregnant women.
US Food and Drug Administration also had a serious warning about this drug, requiring pharmaceutical companies to mark it in bold black text on the homepage of the drug instructions. The first of them is: is teratogenic to the fetus! Even exposure to therapeutic doses as low as 1% can create a significant possibility of fetal malformation.
Therefore, women of childbearing age and their sexual partners should avoid pregnancy within 6 months of using this medicine, and use at least two reliable contraceptive measures (such as oral contraceptives + condoms).
△FDA approved Ribavirin capsules and oral liquids produced by Merck and Schering-Plough, part of the instructions for drug use
Picture source: Visual China
Therefore, remind everyone:
◆ During pregnancy preparation, both men and women should avoid using ribavirin.
◆ If you really need to use ribavirin, you should first confirm that you are not pregnant yet, and take effective contraceptive measures before the treatment starts, during the treatment, and at least 6 months after the drug is discontinued.
◆ Before using ribavirin for your child, be sure to consult a doctor first.
Tips:
Correct use range of ribavirin
In fact, the mechanism of action of ribavirin is not clear. In vitro cell culture experiments show that it has a selective inhibitory effect on respiratory syncytial virus (RSV), but the clinical effect is currently uncertain.
Although ribavirin is called a broad-spectrum antiviral drug, it can treat very single diseases. The only cases that can be used are:
1, patients with viral pneumonia and bronchitis caused by respiratory syncytial virus.
2. Patients with skin herpes virus infection.
3. Ribavirin aerosol can be used for viral rhinitis, pharyngeal inflammation, pharyngeal conjunctivitis or oropharyngeal viral infection.
4. Severe cases of hand, foot and mouth disease.
5. Epidemic hemorrhagic fever.
6. Combined with interferon to the treatment of chronic hepatitis C.
7. Adult measles (no use for children).
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