Traditional influenza vaccines are expected to overcome viral mutations! The research team led by Weng Qihui, a researcher and associate researcher Ma Che, hired a "egg" to create a monosaccharide influenza vaccine that can resist crossstrain influenza virus infection. The defense effect is three to four times higher than that of traditional influenza vaccines. This research result was published in "PNAS" in February this year and obtained patents from multiple countries.
influenza virus will use the mutation of its surface protein molecules to fight the pursuit of host antibodies, so the vaccine strain needs to be changed every year, otherwise it will not be able to resist the infectiousness of influenza . Therefore, the manufacturing of influenza vaccines is the primary solution to the ineffectiveness of the vaccine due to the high variability of the virus.
Mache said: "Using eggs to make monosaccharide flu vaccines is a simple and practical method that can solve the problem of virus mutation." Macher Laboratory uses traditional methods of cultivating viruses with eggs and combined with innovative influenza virus monosaccharification technology to create monosaccharide influenza vaccines against HA protein on influenza viruses. Experiments have proven that compared with the existing influenza virus vaccine, this monosaccharide vaccine has more than three to four times the defense effect on heterogeneous influenza viruses.
study found that the HA antigen protein on influenza virus is responsible for helping the virus catch host cells, which are covered with various polysaccharide molecules. Therefore, they first removed the glycovirus in a string of glycovirus on the surface protein of H1N1, leaving only one glycovirus to maintain structural stability, and then made the monosaccharide virus into an influenza vaccine. Experimental results show that mice vaccinated have a wide-acting immune response in their bodies, which can fight infection with heterogeneous influenza virus. Because removing the glycomic molecules on the surface of the virus is like removing the virus's disguise, leaving it without any hiding under the immune system.
In order to achieve the latest solution, the research team has built a vaccine manufacturing and production platform, using embryonic eggs that have been fertilized for about ten days, to create monosaccharide flu vaccines without transsubtype restrictions within one week.
Mache also said that HA protein is like a mushroom and is prone to mutating on the head to escape the host's immune response. The stems are protected by carbohydrates to prevent them from being identified by the host immune cells . Therefore, when monosaccharide influenza vaccine produces antibodies in the body, it can effectively attack the stems of the virus. Researchers also found that ADCC1 effect is produced on cells infected with the virus, and the immune cells in patients clean up cells that have been invaded by the influenza virus.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-