09 September 11th "Heart Heart Daily", we interpreted 11 documents, focusing on: ultra-processed food, artificial sweeteners, vitamin D, new coronavirus, alcohol consumption, colorectal cancer, skin cancer, acrylamide, breast cancer, nuts, dietary fiber
BMJ: Data from nearly 23,000 people revealed that the association between ultra-processed food and diet quality and mortality
British Medical Journal—[93.333]
① 22,895 Italians were included, 272,960 people-year follow-up period, a total of 2,205 deaths were found; ② Compared with those with the highest diet quality (based on the FSAm-NPS index assessment), the risk of all-cause death and cardiovascular death in the lowest diet quality increased by 19% and 32% respectively; ③ Compared with those with the lowest intake of super-processed food, the risk of all-cause death and cardiovascular death in the highest intake of super-processed food increased by 19% and 27% respectively; ④ The association between diet quality and death risk can be partially explained by super-processed food, while the association between super-processed food and death risk cannot be explained by diet quality.
[Editor's comment] A prospective cohort study published in
British Medical Journal. After more than 10 years of follow-up of nearly 23,000 Italians, it was found that lower dietary quality or higher intake of superprocessed foods is related to higher risk of all-cause death and cardiovascular death. Among them, the association between dietary quality and death risk can be partially explained by superprocessed foods. （@aluba）
【Original information】
Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with motality: Moli-sani prospective cohort study
2022-08-31, doi: 10.1136/bmj-2022-070688
BMJ: Super processed food may increase the risk of colorectal cancer in men
British Medical Journal—[93.333]
① Included in three U.S. cohorts, including 46,341 men and 159,907 women. During the 24-28 follow-up period, 1,294 men and 1,922 women were diagnosed with colorectal cancer, respectively; ② Compared with men with the lowest intake of ultra-processed food, the risk of colorectal cancer in men with the highest intake of ultra-processed food was significantly increased by 29%; ③ Intake of ultra-processed food was not significantly associated with the risk of colorectal cancer in women; ④ ready-to-eat products and sugar-containing beverages based on meat/poultry/seafood were associated with the increased risk of colorectal cancer in men, ready-to-eat products/heated mixed dishes were associated with the increased risk of colorectal cancer in women, and yogurt and dairy-based sweets were negatively associated with the risk of colorectal cancer in women.
[Editor's comment] Results of a prospective cohort study published in
British Medical Journal, after more than 20 years of follow-up of three U.S. cohorts (including more than 200,000 subjects) found that hyperprocessed food intake was associated with an increased risk of colorectal cancer in men (rather than women), and was still significant after correction for BMI and nutritional quality, but it was only significantly associated in distal colon cancer. Subgroup analysis results showed that intake of ready-to-eat products/heated mixed dishes were associated with an increased risk of colorectal cancer in women, while intake of yogurt and dairy sweets were associated with a reduced risk of colorectal cancer in women; while intake of ready-to-eat products and sugary beverages based on meat/poultry/seafood were associated with an increased risk of colorectal cancer in men. （@aluba）
【Original information】
Association of ultra-processed food consumption with colorfull cancer risk among men and women: results from three prospective US cohort studies
2022-08-31, doi: 10.1136/bmj-2021-068921
BMJ: Data from more than 100,000 people revealed that artificial sweeteners may increase the risk of cardiovascular and cerebrovascular diseases
British Medical Journal——[93.333]
① 103,388 participants (mean 42.2 years old, 79.8% were female), and a total of 1,502 cardiovascular events occurred during the median follow-up of 9.0 years; ② The participants' intake of artificial sweetener was evaluated through 24-hour diet records. Total artificial sweetener intake was associated with an increased risk of cardiovascular and cerebrovascular diseases, and the association was more obvious (HR was 1.09 and 1.18, respectively); ③ Aspartame intake was associated with an increased risk of cerebrovascular diseases (HR = 1.17), and the intake of acemeth and sucralose was associated with an increased risk of coronary heart disease (HR was 1.40 and 1.31, respectively).
[Editor's comment] A prospective cohort study published in
British Medical Journal After a nearly 10-year follow-up of more than 100,000 participants, it was found that artificial sweetener intake is associated with an increased risk of cardiovascular and cerebrovascular diseases. （@aluba）
【Original information】
Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohorthamml2
2022-09-07, doi: 10.1136/bmj-2022-071204
BMJ: Vitamin D supplementation cannot prevent acute respiratory infections and new coronary pneumonia
British Medical Journal——[93.333]
① 2674 blood 25(OH)D concentration is lower than 75 Subjects with nmol/L were randomly divided into two groups, supplemented with low doses (800 IU per day, n=1328) and high doses (3200 IU per day, n=1346) of vitamin D; ② Another 2949 subjects were used as control group, and did not receive blood 25 (OH)D concentration test and were not supplemented with vitamin D; ③ The proportion of acute respiratory infections in the low dose, high dose and control group was 5.0%, 5.7% and 4.6%, respectively, with no significant difference; ④ The incidence of new coronary pneumonia in the low dose, high dose and control group was 3.0%, 3.6% and 2.6%, respectively, with no significant difference.
[Editor's Comment] Results of a Phase 3 clinical trial published in
British Medical Journal, compared with subjects who were not supplemented with vitamin D, vitamin D supplementation of 800 IU or 3200 IU daily had no significant impact on the risk of acute respiratory infection and COVID-19. （@aluba）
【Original information】
Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)
2022-09-07, doi: 10.1136/bmj-2022-071230
BMJ: Cod liver oil supplementation in winter cannot prevent new coronary pneumonia and other acute respiratory infections
British Medical Journal—[93.333]
① 34,601 subjects were included, 17,278 were supplemented with 5mL cod liver oil (containing 10μg of vitamin D), and 17,323 were supplemented with placebo daily, and continued intervention for 6 months began in winter; ② Cod liver oil supplementation had no significant improvement effect on the four clinical endpoints, including: RT-PCR-confirmed new coronavirus infection (1.31% vs. 1.32%), severe new coronavirus pneumonia (self-reported dyspnea, hospitalization, death, 0.70% vs. 0.58%); ③ and: at least one negative coronavirus test (49.46% vs. 49.44%), and at least one acute respiratory infection (22.94% vs. 22.13%).
[Editor's Comment] The results of a four-blind randomized placebo-controlled trial published in the British Medical Journal conducted a 6-month intervention on nearly 35,000 subjects. Cod liver oil supplementation (containing low-dose vitamin D) cannot reduce the incidence of new coronary pneumonia and acute respiratory infections, nor can it reduce the risk of severe new coronary pneumonia. （@aluba）
【Original information】
Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial
2022-09-07, doi: 10.1136/bmj-2022-071245
Vitamin D deficiency is correlated with high prevalence of metabolic syndrome
American Journal of Clinical Nutrition—[8.472]
① 8639 adults were included to analyze the correlation between serum vitamin D content and metabolic disease (MetS), and classified according to race and Hispanic ancestry; ② After considering factors such as sociopologia, lifestyle, dietary supplements and body mass index, serum vitamin D was significantly negatively correlated with the overall prevalence of MetS (abdominal obesity, hyperglycemia, triglycerideemia) among all ethnic-Hispanic groups, and this association was stronger among non-Hispanic whites and weaker among Hispanic adults; ③ Compared with the highest tertile (>77.9 nmol/L), serum vitamin D was positively correlated with the risk of MetS in the lowest tertile (≤56 nmol/L).
[Editor's comment]
Some studies have found that the status of vitamin D is negatively correlated with metabolic syndrome (MetS).A recent article by American Journal of Clinical Nutrition found that lower vitamin D was significantly associated with MetS among American adults and was present in all races and Hispanics, especially among non-Hispanic whites. (@Zhang Tailiu)
[Original information]
Vitamin D status and prevalence of metabolic syndrome by race and Hispanic origin in U.S. adults: findings from 2007-2014 NHANES
2022-08-29, doi: 10.1093/ajcn/nqac234
40 years old, may increase the risk of colorectal cancer
European Journal of Epidemiology——[12.434]
① 191,180 European participants (mean 50.2 years) were included, and a total of 1,530 colorectal cancer were diagnosed during the average follow-up period of 7.1 years; ② Compared with those with stable alcohol intake, daily alcohol intake increased or decreased by 12 g during the follow-up period, which was associated with a 15% or a 14% increase in colorectal cancer risk; ③ Another 407,605 participants (including 5,008 colorectal cancer cases) were included to evaluate changes in alcohol intake at 20, 30, 40, 50 years, baseline and follow-up periods; ④ Compared with those with low alcohol intake, daily alcohol intake increased to 30 g in early to mid-to-late adulthood in men, which was associated with a 24% increase in colorectal cancer risk compared with those with low alcohol intake.
[Editor's Comment] A prospective cohort study published in the European Journal of Epidemiology found that an increase in daily alcohol intake in men in the middle and late stages of adulthood (40-50 years old) was associated with an increased risk of colorectal cancer. (@aluba)
[Original information]
A longitudinal evaluation of alcohol intake throughout adulthood and colorful cancer risk
2022-09-05, doi: 10.1007/s10654-022-00900-6
.45 million people cohort results: Drinking alcohol increases the risk of skin cancer!
International Journal of Cancer—[7.316]
① 450,112 participants had 14,037 skin cancers during the 15-year follow-up period; ② Alcohol intake at baseline was linearly positively correlated with the increase in skin cancer risk, especially with squamous cell carcinoma (SCC) and basal cell carcinoma (BCC); ③ The mean alcohol intake in adulthood was also related to skin cancer risk, especially with SCC and BCC in men and BCC in women; ④ Analysis by alcohol beverage type showed that spirits were positively correlated with melanoma and BCC risk in men, while wine intake was related to BCC and SCC risk; ⑤ In women, wine intake was related to increased BCC risk, but no association between beer and skin cancer in men and women was found.
[Editor's comment]
There is experimental evidence that alcohol can induce skin cancer, but epidemiological studies have always had inconsistent links between alcohol intake and skin cancer. The European Prospective Survey of Cancer and Nutrition (EPIC) is a prospective cohort study initiated in 1992 in 10 European countries. A recent study published in International Journal of Cancer used EPIC data to find that alcohol intake and all three skin cancers (melanoma, basal cell carcinoma, squamous cell carcinoma) had a positive correlation, with stronger associations in men than in women, which vary by alcoholic beverage type.(@Registered Nutritionist Chen Binlin)
[Original information]
Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)
2022-08-19, doi: 10.1002/ijc.34253
Intake of acrylamide may increase the risk of premenopausal breast cancer in women
American Journal of Clinical Nutrition—[8.472]
① 80,597 French women (mean 40.8 years) were included, and a total of 1,016 breast cancers were diagnosed during the 8.8 years of follow-up. (431 premenopausal and 585 postmenopausal); ② Acrylamide intake was evaluated through multiple 24-hour diet reviews. The average daily acrylamide intake was 30.1μg, mainly from coffee, fries, potato chips, desserts, cakes, and bread; ③ Compared with those with the lowest acrylamide diet, the risk of breast cancer intake of the highest acrylamide diet increased by 21%, especially the risk of premenopausal breast cancer increased by 40%; ④ Acrylamide intake was positively correlated with (total and premenopausal) estrogen receptor-positive breast cancer risk.
[Editor's comment]
American Journal of Clinical Nutrition results showed that after following up more than 80,000 French women for about 9 years, it was found that the higher the dietary intake of acrylamide, the higher the risk of premenopausal breast cancer. （@aluba）
【Original information】
Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Santé cohort
2022-09-02, doi: 10.1093/ajcn/nqac167
Nut intake is beneficial to health
Advances in Nutrition——[11.567]
① Evidence of moderate quality shows that intake of nuts is related to the reduced risk of cardiovascular disease and related risk factors; ② Compared with those who do not consume nuts, daily intake of 28g nuts was associated with a 21% reduction in cardiovascular disease risk (including coronary heart disease incidence and mortality, atrial fibrillation incidence, stroke mortality) 22% reduction in cancer death risk, and all-cause death risk; ③ Nut intake was associated with a reduced risk of respiratory diseases, infectious diseases and diabetes; ④ The results of meta-analysis of trials of biomarkers were consistent with the results of meta-analysis of observational studies on diseases; ⑤ 1-2% of adults had allergies to nuts and related adverse reactions.
[Editor's comment] An umbrella-like review published on
Advances in Nutrition summarized the results of 89 meta-analysis, and nut intake is related to cardiovascular disease risk, cancer death risk, all-cause death risk, respiratory disease death risk, infectious disease death risk and diabetes death risk. （@aluba）
【Original information】
Consumption of Nuts and Seeds and Health Outcomes Including Cardiovascular, Diabetes and Metabolic Disease, Cancer, and Mortality: an Umbrella Review
2022-08-30, doi: 10.1093/advances/nmac077
Dietary fiber is good for health, but intake is not the better for the better (review)
Advances in Nutrition—[11.567]
① This review included 103 clinical trials to investigate the tolerance of undigestive carbohydrates (NDCs) such as β-glucan, pectin, etc. in adults without gastrointestinal diseases (such as abdominal distension, bloating, and abnormal intestinal jingling); ② These studies used doses of 0.75-160 g/d, and the duration of observation ranged from single meal tolerance to 28 weeks; ③ Adults' tolerance to NCDs is species-specific, specifically, alginic acid is 3.75 g/d and soy fiber is 25 g/d; ④ Future studies should fill the gaps in existing studies by testing a wider range of NDC doses and intake forms (solid or liquid).
[Editor's Comment]
Undigestible Carbohydrates (NDCs) are food ingredients, including non-starch polysaccharides and resistant starch, and many NDCs are listed as dietary fiber by the FDA. Due to their potentially beneficial effects on human health, NDCs are widely used in food supply. Although there are dietary intake recommendations for total dietary fiber (14g/1000kcal), specific recommendations for different NDCs are currently lacking.A recent review published in Advances in Nutrition investigated the gastrointestinal effects and tolerance of NDCs that meet the FDA's dietary fiber definition and found that the tolerated intake range of various NDCs is 3.75-25 g/d. However, most NDCs are not yet sure of the final recommended tolerated dose, and more research is needed. (@Registered Nutritionist Chen Binlin)
[Original Information]
Gastrointestinal Effects and Tolerance of Non-Digestible Carbohydrate Consumption
2022-08-30, doi: 10.1093/advances/nmac094
Thanks to the creators of this issue of the daily report: aluba, Rustypotatis, mustard, registered nutritionist Chen Binlin
Click to read the daily report of the past 10 days:
09-06 | Immune cell migration: How does the intestine become the "core" of inflammatory diseases?
09-03 | Fungus/nutrition/metabolism, multi-view focus on diabetes and obesity
09-02 | Today's Cell: Are enteric bacteria also "choosy to eat"? New method in-depth analysis of
09-01 | In August, the 30 most worth reading intestinal health literature! ·
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-