too long to read the version
1 As early as 1520, hydrogen was discovered
2 For a long time, hydrogen was considered to have no biological effect
3 Until 1975, American scientist Dole first discovered the biological effect of hydrogen, which was a complete 455 years apart.
When a new thing appears, it is normal to have doubts and distrust. Just like before 1969, people never imagined that they could stand on another planet - the moon by virtue of human power. The distrust of hydrogen is more due to people's lack of understanding of hydrogen. They do not know much about hydrogen science, or believe in the "pseudoscientific theory" of hydrogen therapy created by some people who criticize hydrogen science.
There is no doubt that hydrogen science is booming at an incredible speed. hydrogen therapy research is moving towards the pyramid. Research with various characteristics is providing increasingly powerful evidence for scientific progress.
- As of 2021, there have been more than 1,600 hydrogen biomedical research papers, more than 100 applications for the National Natural Science Foundation, and more than 60 clinical studies are underway or have been completed.
- According to incomplete statistics, there are 33 registered projects in total, with a time span from 2013 to the present, and the registered projects in 2020 have seen a small peak, which may be related to the fact that the third category of medical equipment obtained national certification that year. Some projects have been completed and published, while others have not been completed or are in progress. Among them, there are more than 3 registrations for medical research institutions located in Shanghai, Shandong, Tianjin and Heilongjiang, and , Shandong First Medical University, registrations for 4.
Hydrogen Medical Clinical Trial Registration Unit (2013-2021)
You may not be unfamiliar with hydrogen. In recent years, it has begun to become popular in China, and has successively appeared, led by research teams such as Sun Xuejun, Zhong Nanshan, Tsui Harkcheng , and Qin Shucun and published a series of hydrogen medical human experiment articles. In fact, there has been a craze for hydrogen in Japan, South Korea and other countries, and hydrogen water was once regarded as the water of the future.
In fact, hydrogen has indeed been proven to have certain intervention or relief effects in various inflammation-related diseases such as chronic metabolic diseases, three highs, cerebral infarction, skin diseases, , etc.
1 The magical hydrogen was discovered 500 years ago?
Hydrogen was first discovered and described as a flammable gas by Swiss chemist Philippus Aureolus Paracelsus in 1520. In 1671, the famous philosopher, chemist, physicist and inventor of Robert Boyle once expressed the properties of hydrogen. It was the first time in the world to collect hydrogen by using the mercury tank method and conducted a comparative systematic experimental observation.
Later, the famous French chemist Lawrence Lavoisier confirmed in 1787 that hydrogen was an element, named this gas "water-forming element", and pointed out that water is not an element, but a compound of hydrogen and oxygen. Until today, hydrogen is named water in Japanese .
To this day, you can still see many hydrogen water jars in Japan with "water water" printed on them
2 Hydrogen medical concept proposed and evaluation
Based on the characteristics of hydrogen, it was initially used as the carrier of airbag , and then it was widely used in spacecraft . In addition to its application value in the energy field, hydrogen is receiving increasing attention as a new medical gas. It is recognized as a selective scavenger of reactive oxygen species (ROS) and especially hydroxyl (•OH), which is related to the occurrence and progression of many pathological states, including cancer.
As early as 1937, hydrogen was first tested as a submersible gas, proving that hydrogen is the best respiratory medium for moderate and deep diving and is extremely safe for the body. did not find any toxic side effects .
It was not until recent decades that the biological effects of hydrogen were discovered one after another. In 1975, American scientists Dole and others reported in the journal Science. After 8 atmospheric pressures of high-pressure hydrogen treatment for skin squamous cell carcinoma mice, they found that the tumor was significantly reduced. This is the first time in human history that hydrogen has a biological effect . However, due to safety considerations, the study did not receive much attention at the time.
In 2007, Oda Naio Oda and others published a paper in "Natural Medicine", reporting that hydrogen has obvious treatment effect on the model of cerebral infarction in rats. Experimental data show that intake of 1%-4% hydrogen can reduce the area of cerebral infarction in rats. They further pointed out that hydrogen has the effect of specifically removing •OH and peroxy nitrite , but does not affect hydrogen peroxide or superoxide, and opens a new chapter in hydrogen medicine. The result of has aroused the interest in the biological role of hydrogen in the medical field and its clinical significance for various diseases in the human body, which has prompted more and more attention to the value of hydrogen to life and health in the fields including medical, science and technology, industry and capital.
In 2008, Professor Sun Xuejun's team of Professor Sun Xuejun of the Second Military Medical University published the second international article and the first domestic hydrogen medicine research report. Professor Sun Xuejun is the most important advocate and promoter of domestic hydrogen medicine research and is known as "the first person in China's hydrogen molecules."
2017 , Guangzhou Fuda Cancer Hospital, , President Professor Tsui Harkcheng, created a hydrogen medicine experience hall with hundreds of people. provides free rehabilitation experience for cancer patients, achieving great clinical results in hydrogen-assisted tumor rehabilitation medicine, and published the book "Hydrogen Cancer Control", which shocked the hydrogen medicine research community.
Looking at the development of medicine, a new scientific discovery and technological invention requires solid scientific research as support, especially methods or products with medical effects, and their impact on normal physiological functions must be clarified. This is a basic scientific issue and a process that requires long-term accumulation. The concept of "hydrogen medicine" was gradually established through this process.
3 Some important experiments on hydrogen
The earliest report on the biological role of hydrogen was Dole et al. They found that 97.5% of hydrogen was continuously intake at 8 atmospheres. After two weeks, the squamous cell carcinoma of the mouse skin shrunk significantly. They speculated that hydrogen may be a catalyst for free radical reactions. Due to the special experimental conditions and poor repeatability, this study could not be carried out.
Then Gharib et al. found that breathing 7 atmospheres of hydrogen has a significant therapeutic effect on inflammation after parasitic infection in mice. proved for the first time that hydrogen has an anti-inflammatory effect. and proposed that the direct reaction of hydrogen with OH is the basis for its treatment of inflammatory damage, but they also did not carry out any subsequent research work. Although these individual studies have shown some phenomena in the treatment of certain diseases, they have not aroused the interest of other scholars due to unknown mechanisms, poor research, and the need for high-barometric conditions.
2007 Ohsa⁁wa et al. published a paper in Nature Medicine, proving that intake of a small amount of hydrogen (2%) under normal pressure can effectively treat ischemic stroke in rats, and proposed that hydrogen can selectively remove free radical , that is, hydrogen has a selective antioxidant effect. This discovery officially kicked off the study of hydrogen molecular biology.
2008 Nakao and others reported for the first time that continuous intake of 2% hydrogen could prevent peristaltic disorders after small intestine transplantation in rats, significantly enhance the contractility of jejunal smooth muscles, alleviate intestinal mucosal morphological damage, and significantly decrease the MDA level of the end product of lipid peroxidation in the graft. The mRNA of several important inflammatory molecules was determined by quantitative PCR, such as CC group chemokine 2 (CCL2), cytokine interleukin 1β (IL1-beta), cytokine interleukin 6 (IL-6) and tumor necrosis factor α (TNF-alpha), etc. found that hydrogen could significantly inhibit the upregulation of inflammatory factors induced by transplantation.
Then they proved that respiratory hydrogen has a protective effect on heart transplantation injury, lung injury after lung transplantation and chronic transplantation nephropathy. In addition to antioxidant, they proposed that this protection of hydrogen may be related to 's enhancement of the body's anti-inflammatory effects and induction of the antioxidant enzyme HO-1.
Recently, Tan et al. found that as long as hydrogen is dissolved into the organ preservation solution, the gene expression level of apoptotic protein in the heart cells to be transplanted will be significantly reduced, and the oxidative damage will be significantly reduced. The heart is preserved at 4°C in vitro. The time for the heart recovery beating in the control group is about 4 minutes, while the time for the heart recovery beating in the hydrogen-containing protective solution will be reduced to 1 minute, and the effect of heart preservation is significantly improved. The above study shows that hydrogen has the potential application value of organ protection from the storage of isolated organs to the damage after organ transplantation.
After that, hydrogen has been discovered in the prevention and treatment effects of experimental animals including radiation damage, organ ischemia, arteriosclerosis, cirrhosis, oxygen poisoning, diabetes , organ and system inflammation, trauma, Bakinson's disease, senile dementia , carbon monoxide poisoning, paraquat poisoning and other prevention and treatment.
4 hydrogen has been given an indestructible legal status around the world
1, US Food and Drug Administration FDA Catalog for adding hydrogen water to drinking water in 2014;
2, China Health and Family Planning Commission 2014 GB2760-2014 hydrogen is an unlimited food additive;
3, China Health and Family Planning Commission 2015 GB31633-2014 "National Food Safety Standard Food Additive Hydrogen" Hydrogen is issued as a food additive;
4, Korea Food and Drug Safety Department Hydrogen was approved as a food additive in 2015;
5. Japan Ministry of Health and Health approved in 1955. Hydrogen Food Additive List No. 168;
6. In 2016, it was recognized as an advanced medical method in Japan. On December 1, Japan officially approved "hydrogen inhalation therapy" to become a "advanced medical B" treatment method;
7 and EU implemented the "negative list system" to exclude hydrogen from the negative list;
8. On February 2, 2020, the China National Medical Products Administration approved the first hydrogen and oxygen atomizer as a third-class medical device;
9. Hydrogen and oxygen mixed inhalation treatment was promulgated by the state for the seventh edition of the diagnosis and treatment plan for the new coronavirus pneumonia.
5 HM4 Summary of Clinical Literature of Hydrogen Medical
1.Huang KC, Yang CC, Lee KT, Chien CT. 2003;64(2):704–14. Early clinical study of hydrogen-containing electrolyzed water , uremia
2.Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, 2008;28(3):137–43 Hydrogen water for diabetes.
3.Nakayama M, Kabayama S, Nakano H, Zhu WJ, Terawaki H, Nakayama K, 2009;112(1):c9–15. Electrolytic dialysate
4.Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. . 2010;46(2):140–9 Hydrogen water treatment of metabolic syndrome
5.Nakayama M, Nakano H, Hamada H, . 2010;25(9):3026–33. Hydrogen water dialysis
6.Ono H, Nishijima Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, 2011;1(1):12. Comparative treatment of brainstem ischemia with hydrogen and edalavone .
7. Ito M, Ibi T, Sahashi K, Ichihara M, Ito M, .2011;1(1):24. mitochondrial and inflammatory musculosis
8. Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T,.2011;1(1):11. Quality of life decreased after radiation therapy
9.Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, .2012;2(1):14. 4 cases of acute skin disease
10.Ostojic SM. 2012;87(5):501–2. Hydrogen water acidification of blood after exercise
11. Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, 2012;2(1):27. Treatment of high concentration of hydrogen water on rheumatoid arthritis
12. Shimouchi A, Nose K, Shirai M, 2012;737:245–50. Analysis of human hydrogen consumption after drinking hydrogen water
13.Ono H, Nishijima Y, Adachi N, Sakamoto M, 2012;2(1):21. Study on the safety of hydrogen inhalation in patients with acute cerebral ischemia
14.Aoki K, Nakao A, Adachi T, Matsui Y, 2012;2(1):12. Hydrogen water on muscle fatigue after acute exercise
15.Song G, Li M, Sang H, Zhang L, Li X, Yao S, 2013;54(7):1884–93. Effect of Hydrogen water on blood LDL cholesterol levels
16.Shimouchi A, Nose K, Mizukami T, 2013;789:315–21. Study on the human body's consumption of hydrogen after hydrogen inhalation
17.Yoritaka A, Takanashi M, Hirayama M, 2013;28(6):836–9. Double-blind placebo-controlled trial of drinking hydrogen water for Parkinson's disease .
18.Nagatani K, Nawashiro H, Takeuchi S, Tomura S, 2013;3(1):13. Safety evaluation of intravenous hydrogen saline in treatment after acute cerebral ischemia.
19.Li Q, Kato S, Matsuoka D, 2013, 3(1):20-20. Evaluation of the effect of hydrogen water gavage on the treatment of bedsores
20. Xia C, Liu W, Zeng D, Zhu L, Sun X, 2013;6(5):372–5. Treatment of hydrogen water on chronic hepatitis in humans
21.Tsumoto S, Ueda T, 2013;81(2):226–30. Treatment of hydrogen water on interstitial cystitis to relieve pain!
22.Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, 2013;3(1):14. Hydrogen gas is dissolved in dialysate , uremia peritoneal dialysis after oxidative stress.
23.Lucas K, Maes M. 2013;34(8):723-37. PMID: 24522022. In a case of chronic fatigue syndrome, the German professor author himself is the subject.
24. Takeuchi S, Mori K, Arimoto H, 2014;14:176. Randomized controlled trial study on the treatment of hydrogen water on subarachnoid cerebral hemorrhage in severe hemangioma rupture.
25.Terawaki H, Zhu WJ, Matsuyama Y, Terada T, 2014;18(2):459–66. Effect of hydrogen dissolved hemodialysate on albumin redox modification.
26.Sakai T, Sato B, Hara K, Hara Y, 2014;10:591–7. Study on improving the function of in vascular endothelial cells in healthy people.
27.Ostojic SM, Stojanovic MD. 2014;22(1):49–60. Study on the acidification of hydrogen water on blood after exercise
28.Ostojic SM, Vukomanovic B, 2014;126(5):187–95. Improving effect of oral hydrogen tablets on soft tissue damage after exercise.
29.Ishibashi T, Sato B, Shibata S, Sakai T, 2014;21(2):468–73. Double-blind placebo controlled trial demonstrates the therapeutic effect of hydrogen saline on rheumatoid arthritis.
30.Tanikawa R, Takahashi I, Okubo N, Ono M, 2015;65:138–46 Research on the relationship between hydrogen levels and human neutrophil function.
31.Tamasawa A, Mochizuki K, Hariya N, 2015, 762:96-101 Single oral administration of acarbose promotes the intestinal production of hydrogen on the inflammatory response of peripheral blood of type 2 diabetes.
32.Terawaki H, Nakano H, Zhu WJ, 2015;35(1):107–12. The therapeutic effect of hydrogen dissolved dialysate on peritoneal sclerosis.
33.Nakata K, Yamashita N, Noda Y, 2015;5(1):2. The role of hydrogen on human sperm motor ability.
34. Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, 2015;12(2):2757–64. The therapeutic effect of hydrogen on psoriasis-related arthritis and skin lesions.
35.Song G, Lin Q, Zhao H, Liu M, Ye F, Sun Y, 2015;100:2724–33. Double-blind placebo controlled trial Clinical trial of hydrogen improving the function of high-density lipoprotein .
36.Tange Y, Takesawa S, 2015;7(2):e26847. Protective effect of hydrogen dialysis on blood albumin.
37.Azuma T, Yamane M, Ekuni D, Kawabata Y, 2015 Jul 9;4(3):513-22. Hydrogen water as an auxiliary treatment of periodontitis
38.Igarashi T, Ohsawa I, Kobayashi M, 2016 Aug 8;6:31190. Protective effect of hydrogen on endothelial cell damage during surgical procedures.
39.Qian LR, 2016 Oct 14;6(3):177-179. Case reports of hydrogen water on graft-versus-host disease
40.Tamura T, Hayashida K, 2016;80: 1870–3 Safety study of hydrogen gas in patients with cardiac arrest syndrome
41.Yoritaka A, Abe T, Ohtsuka C, 2016 May 12;16:66. Multi-neutral study protocol for hydrogen water on the treatment of Parkinson's disease.
42.Katsumata Y, Sano F, 2017, 81(7):940-947. Effect of hydrogen inhalation on cardioprotective effects of myocardial infarction after interventional surgery.
43.Korovljev D, Trivic T, 2017:1-5. Effect of hydrogen on metabolism and mitochondrial function in overweight women
44.Mizuno K, Sasaki A, 2017, 7(4):247. Hydrogen water improves anxiety and autonomic function
45.Tamura T, Hayashida K, Sano M, 2017 Oct 23;18(1):488. Clinical research protocol
46.Nakayama M, Itami N, Suzuki H, 2017 Sep 13;12(9):e0184535. The role of hydrogen as a chronic dialysis patient
47.Nakayama M, Zhu WJ, 2017 Oct 31;18(1):327. The role of hydrogen on peritoneal integrity of patients with peritoneal peritoneal .
48.Yang Q, Ji G, Pan R, Zhao Y, 2017 Nov;7(5):891-896. Research on the protection of hydrogen water on liver function after chemotherapy
49.Ono H, Nishijima Y, Ohta S, 2017. Clinical study of hydrogen inhalation on acute cerebral ischemia.
50.Nishimaki K, Asada T, Ohsawa I, Nakajima E, 2018 Mar 14;15(5):482-492. Randomized clinical trial of hydrogen on chronic cognitive impairment
51.Nakayama M, Itami N, Suzuki H, 2018 Jan 10;8(1):254. Effects of hydrogen dissolving dialysate on uremia dialysis
52.Zhu, Q., Wu, Y., Li, Y. et al. (2018). https://doi.org/10.1038/s41598-018-26388-3 Therapeutic effects of hydrogen bathing on psoriasis
53. Franceschelli S, Gatta DMP, 2018 May;22(5):2750-2759. Regulation of water-rich molecular hydrogen on oxidative plasma state in gastroesophageal reflux disease: a new biological perspective
54. Tanaka Y, Saitoh Y, Miwa N. 2018 Apr 18;8(1):12-18. Effects of electrolytic water on blackhead and capillary blood flow
55. Tanaka Y, Saihara Y, Izumotani K, Nakamura H. 2019 Jan 9;8(4):160-166. Effect of electrolytic reducing water on healthy people and patients with gastrointestinal diseases
56. Hirayama M, Ito M, Minato T, 2019 Jan 9;8(4):144-149. Effect of hydrogen inhalation on 8-hydroxydeoxyguanine levels in urine in Parkinson's disease.
57.LeBaron TW, Larson AJ, Ohta S, 2019 Jan;9(1):36-43. Hydrogen molecules are beneficial to submaximum motion index. Randomized, double-blind , placebo-controlled cross-trial study.
58.Chen JB, Pan ZB, Du DM, Qian W, 2019 Aug 6;7(15):2065-2074. Report of 1 case of contraction caused by metastatic gallbladder cancer caused by hydrogen treatment
59.Chen JB, Kong XF, Lv YY, Qin SC, Sun XJ, 2019 Jul-Sep;9(3):115-121. Real-world observation follow-up of 82 cases of cancer treated with hydrogen
60.Chen J, Mu F, Lu T, Ma Y, 2019 Oct 18;12:8645-8651. A patient with gallbladder cancer showed pseudo-progress relief after inhaling hydrogen.
61.LeBaron TW, Singh RB, Fatima G,2020 Mar 24;13:889-896. Effect of high concentration of hydrogen water on metabolic syndrome such as body weight blood lipids .
62.Wang ST, Bao C, He Y, Tian X, 2020Dec 1;113(12):870-875. Hydrogen inhalation for asthma and COPD
63.Sim M, Kim CS, Shon WJ, 2020 Jul 22;10(1):12130. Double-blind placebo-controlled trial in healthy adults reduces apoptosis and inflammation of peripheral blood leukocytes in healthy adults
64.Akagi J, Baba H. 2020 Nov;20(5):258. Small cell lung cancer Cancer immunotherapy hydrogen inhalation
65.Tamura T, Suzuki M, Hayashida K, 2020 Sep;67(2):214-221. Oxidative stress indicators for cardiac arrest syndrome
66.Qian L, Liu M, Shen J, Cen J, Zhao D. Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial. Front Immunol.2020 Nov 25;11:598359. Single-arm multi-neutral open phase II clinical trial of graft-versus-host disease
67.Guan WJ, 2020;12(6):3448-3452. Multicenter open clinical trials study hydrogen treatment for new coronary pneumonia
68.Hori, A., Sobue, S., Kurokawa, R., Hirano, S. I., Ichihara, M., & Hotta, N. (2020). 10(4), 163. 2 weeks of continuous hydrogen water supplementation to provide maximum oxygen uptake during exercise in healthy people, double-blind placebo-controlled trial
69.Hori, A., Ichihara, M., Kimura, H., Ogata, H., Kondo, T., & Hotta, N. (2020). 10(3), 96. Effect of hydrogen inhalation on ketone levels after exercise, randomized single-blind placebo-controlled trial
70.Kato, S., Takada, Y., & Miwa, N. (2021). 95, 102805. Human trial of hydrogen bathing to regulate body temperature.
71.Hong, C. T., Hu, C. J., Lin, H. Y., & Wu, D. . (2021). Effects of concomitant use of hydrogen water and photobiomodulation on parkinson disease: a pilot study. Medicine, 100.
72.Chilicka K, Rogowska AM, Szyguła R. 2021 Feb 1;9(2):144. Treatment of acne by hydrogen
73.Alharbi AAD, Ebine N, Nakae S, Hojo T, 2021 Jan 30;13(2):459. Application of molecular hydrogen as an antioxidant in the response to ventilation and energy metabolism regulation in incremental exercise of human body.
74.Kubota M, Kawashima M, Inoue S,2021 Mar 19;11(1):6434. Randomized cross-clinical study on dry eye disease
75.Gu, Q., Liu, B., Xue, J., Zhao, M., Zhang, X., Wang, M., ... & Qin, S. (2021). Effects of drinking hydrogen-rich water in men at risk of peripheral arterial disease: a randomized placebo-controlled trial. Double-blind placebo-controlled trial of hydrogen water for peripheral vascular disease
76.Botek M, Krejčí J, McKune AJ, Sládečková B, 2019 Dec;40(14):879-885. doi: 10.1055/a-0991-0268. Epub 2019 Oct 1. PMID: 31574544. Hydrogen-rich water improves movement of ventilation, perception and lactic acid reactions.
77.Botek, Michal & Krejci, Jakub & Mckune, Andrew & Valenta, Michal & Sládečková, Barbora. (2021). The consumption of hydrogen-rich water positively affects muscle performance, lactic acid response, and reduces the delayed onset of muscle soreness after resistance training.
78.Botek, Michal & Sládečková, Barbora & Krejci, Jakub & Pluhacek, Frantisek & Najmanová, ELiška. (2021). Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy women. Acta Gymnica. 51. 10.5507/ag.2021.009. Acute hydrogen-rich water intake stimulates cardiac autonomic activity in healthy women.
79.Hirano Si, Aoki Y, Li XK, Ichimaru N, 2021;11:104-9 Protective effect of hydrogen inhalation on radiotherapy bone marrow injury
80.Si Y, Tian H, Dong B, Zhang Y, Wen Y, Jia X, Li Y, Zhang A, 2021 Apr 25. Adjuvant treatment of hydrogen on unstable angina pectoris
81.Zheng, ZG., Sun, WZ., Hu, (2021). Double-blind placebo-controlled trial of Zhong Nanshan's team on improving clinical symptoms during acute onset of COPD by hydrogen inhalation.
Chinese hydrogen medicine clinical research paper:
82. Song Zhan, Wang Xiaosheng, Wang Fengli. Observation on the clinical efficacy of hydrogen inhalation treatment on chronic obstructive pulmonary disease [J]. Journal of Central South Medical Sciences. 2020(02):128-130
83. Wang Xiaoying, Xu Changchun. Clinical study of 64 cases of Parkinson's disease with hydrogen-rich water [J]. Journal of Naval Medicine. 2021(01):108-109
84. Cheng Bingfeng. Research on the effect of hydrogen inhalation on renal function and quality of life in patients with chronic kidney disease [D]. Naval Medical University of the People's Liberation Army of China. 2020.
85. Ji Chengcheng. Research on the effect of hydrogen-rich water on the antioxidant ability of cyclists [D]. Shanghai Institute of Physical Education. 2019
86. Wang Zicheng, Zhang Ye, Wang Gang, Xie Keliang, Yu Yonghao, Wang Guolin. Hydrogen improves the blood levels of oxidative stress and inflammatory factors in patients with coronary artery bypass transplantation. International Journal of Anesthesiology and Resuscitation. 2019(08):720-724
87. Yu Yingying, Su Xiao, Yang Guanghui, Mao Jianchun, Su Li. Clinical observation of hydrogen-rich hydrotherapy to relieve pain of ankylosing spondylitis [J]. Chinese Journal of Rehabilitation Medicine. 2019(02):192-193+203
88. Yuan Yuqing, Zhang Yucheng, Jin Zhao, Zheng Yanyan, Chen Zhiye. Effect of hydrogen-rich liquid on the treatment of anal margin edema after mixed hemorrhoid exfoliation and internal surgery [J]. Jiangsu Medicine. 2019(03):246-248
89. Zhang Mingyue. Long-term comparative study on antioxidant and motor function of young women's football athletes [D]. Suzhou University. 2018.
90. Chen Li. Research on the clinical effect of hydrogen-rich water drinking in patients with carotid atherosclerosis [D]. Taishan Medical College. 2018.
91. Yu Yang, Zhao Yunlai, Song Guohua, Qin Shucun. Effects of hydrogen and oxygen mixture on skin blood perfusion in healthy people [J]. Chinese Journal of Arteriosclerosis. 2018(06):557-560.
92. Liu Gang, Wang Ruyi, Yu Yonghao, Xie Keliang. Effects of hydrogen inhalation on postoperative delirium in hip fracture in elderly patients [J]. Journal of Clinical Anesthesiology. 2018(07):643-646
93. Zhou Xiao, Qian Cheng, Lu Jiao, Li Xianmeng. Effects of hydrogen on oxidative stress in community diabetes patients and influencing factors [J]. Journal of Community Medicine. 2018(12):1-3
94. Xu Changchun, Li Yanfei, Liu Chengjun, Liu Shufeng. Clinical observation of 110 cases of radioactive oral mucosal reactions with hydrogen-rich water [J]. China Radiation Health. 2018(04):363-365.
95. Zhang Zhe. Basic and clinical research on the treatment of spinal cord injury with high concentration of hydrogen inhalation [D]. Bengbu Medical College. 2017. Wang Ruyi. Effect of hydrogen inhalation on postoperative cognitive dysfunction in elderly patients with orthopedics [D]. Tianjin Medical University. 2017
96. Zhang Guangjie. Effect of high concentration of hydrogen inhalation therapy on non-alcoholic fatty liver disease in the community [D]. Taishan Medical College. 2017.
97. Li Ruotong. Experimental study on hydrogen molecules inhibiting the inflammatory microenvironment of human breast cancer [D]. Taishan Medical College. 2017.
98. Zheng Yansong, Han Chaojin, Chen Zhilai, Zeng Qiang. Research on the treatment effect of hydrogen on male hyperuricemia [J]. Chinese Journal of Clinical Health. 2017(02):118-121
99. Jin Ling, Xu Wen, Zhang Xiaolin, Chang Yongjun, Liu Shuangxi, Zhang Xi, Yu Shaoqing. Effects of hydrogen-rich 0.9% sodium chloride solution for allergic rhinitis [J]. Shanghai Medicine. 2017(06):379-380
100. Gong Zhijing, Guan Jitao, Ren Xuezhu, Meng Deyang, Zhang Huiran, Wang Boli, Yan Xixin. Research on the protective effect of hydrogen on the lungs of haze exposure for sanitation workers. Chinese Journal of Tuberculosis and Respiratory. 2016(12):916-923
101. Hu Jing. Comparative study of different antioxidants on the antioxidant system functions of medium and short distance swimmers [D]. Suzhou University. 2014.
102. Yang Qingxi. Discussing the attenuation and synergistic effect of hydrogen-rich water in chemotherapy for patients with malignant tumors [D]. Taishan Medical College. 2014.
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Warm reminder: This article is for information exchange only and does not guarantee its scientificity, effectiveness, etc. in any form. Hydrogen water cannot replace drugs. According to scientific research, it can be used as auxiliary function health care water. I hope readers will have a reasonable understanding of hydrogen hydration. If the content involves health advice, it is for reference only and should not be used as a basis for health guidance.
