Before starting today’s topic,
would like to ask everyone a question: Are you constipated?
I just heard doctors from the Department of Neurology chatting two days ago.
Handsome Doctor: Last week, "Science Translational Medicine" published a new result from the Van Andel Institute in the United States: People who have had their appendix removed suffer from Parkinson's disease. The risk with was 19.3% lower than without having the appendix removed.
Cool doctor: Before , there was no "constipation" hypothesis. Scientists found that most Parkinson's patients have symptoms of constipation...
I suddenly felt bad when I was constipated.
What is the difference between the appendix and Parkinson's disease? relation?
It feels like two people who are incompatible with each other.
Even if they are distant relatives,
should belong to the kind of people.
The son of a cousin’s daughter, a nephew’s aunt’s cousin,
The editor chose to abstain... But! Even if the appendix is related to Parkinson's disease, why is it related to constipation?
So, the editor consulted Chief Physician Lin Zhijian and Chen Xuhui, Chief Physician of Neurology at Peking University Shenzhen Hospital. Only after did I know that the scientific community’s bold conjecture about Parkinson’s disease could be said to have been passed all the way and deepened layer by layer! Shocking every step of the way!
Bronze rank guess ▶
◀ Is Parkinson’s disease related to constipation?
The cause of Parkinson's disease is very complex. The main reason is the aging of the nervous system, as well as genetic and environmental factors. However, the specific pathogenesis is not yet fully understood. Many people may want to say: What does the "little tail" of the appendix have to do with Parkinson's disease?
This can be traced back to this discovery: As early as many years ago, scientists studying Parkinson's disease discovered that many Parkinson's patients had symptoms of constipation in the first few years or even twenty or thirty years of the disease, so they He made very bold assumptions, including a scientist named Heiko Braak, who proposed the famous intestinal origin theory of .
golden rank guess ▶
◀The root cause of Parkinson's disease is the gastrointestinal tract?
If constipation is indeed one of the symptoms, it must be a health problem with the gastrointestinal tract. So scientists began to study the gastrointestinal tract of patients with Parkinson's disease. As expected, they were found in the gastrointestinal mucosa of such patients. and α-synuclein was found in the appendix. What is alpha-synuclein? To put it simply and crudely, it is an abnormal component of the nerve cells of patients with Parkinson's disease. Thus, the battle between α-synuclein and scientists has begun again!
Scientist: cut the appendix! If α-synuclein is reduced, the prevalence of Parkinson’s disease will naturally be lower.
α-Synuclein: Hey hey, little boy~ I’m not just in the appendix, don’t forget I can also reproduce in the gastrointestinal mucosa!
Having said that, if one of the "criminal gangs" of this brain disease is willing to stay in the stomach and don't go to the brain to cause trouble, nothing will happen. But they are not fuel-efficient lamps. After breeding too much, and watching their family slowly grow stronger, they will become malicious. If they are bold and their brains are hot, they will summon their accomplices: Brothers, rush! Get into your head and control him! How to change
? There has to be a way. There is indeed a "gut-brain pathway" called the vagus nerve. So all the soldiers and horses were gathered together, and they left at once and captured the "fortress" in one fell swoop. Parkinson's disease symptoms such as slow movement and trembling hands came to the door. This is a naked challenge to scientists! can be tolerated, but cannot be tolerated! Scientists are at it again: cutting off the vagus nerve!
So there are currently two opinions on reducing the incidence of Parkinson's disease: Either cut the source (appendix removal), or block the transport pathway (vagus nerve removal).
King's Rank Therapy ▶
◀ "Eat...eat Xiang"......
However, these are all methods that treat the symptoms rather than the root cause. If the faucet is broken and water keeps leaking out, you can't When it comes to repairing faucets, keeping the water blocked is not an option!
Based on this hypothesis of intestinal origin, smart scientists once again used their wild imagination to propose a very disgusting and heavy-tasting treatment conjecture: fecal bacteria transplant ! It is to restore the balance of the intestinal microflora of healthy volunteers by spraying the bacterial colonies in the feces of healthy volunteers through endoscopes or allowing patients to take them orally.
Hehehe, brother dei~ In 2013, the US SFDA has included "fecal bacterial transplantation" technology into observational new drug supervision, and also included it in clinical diagnosis and treatment guidelines for the treatment of " pseudomembranous colitis ". In other words...fecal bacterial transplantation has evolved from a "folk remedy" to a "formal therapy."
Fecal microbial transplantation is not just a conjecture. Scientists have found that it can be beneficial to diabetes, obesity, constipation, Crohn's disease, irritable bowel syndrome, chronic fatigue syndrome, depression, autism, etc. There are treatments for chronic diseases, and such treatments do exist.
Other people’s feces may be your life-saving straw! Although this method has not yet been actually applied in the treatment of Parkinson's disease, neuroscience is developing so rapidly. Maybe in a few years, the declaration of being single will no longer be: "I have a car and a house and I can still treat you well", but Is it "I am willing to 'transplant' all my healthy poop to you, can you marry me?"
Okay, if you were confused before? It doesn’t matter, let’s summarize:
1. Constipation may be the earliest symptom of Parkinson’s disease
(But it is not advisable to take laxatives casually!)
2. The “source of crime” of Parkinson’s disease is in the gastrointestinal tract
3. “Eating” can Treating Parkinson's disease
4. At present, the above three points are just bold assumptions
If you want to be careful to verify...
Just kidding, verification is a matter for scientists
Never take risks
So this method has been definitely verified Before
I came to Parkinson's Disease Clinic of Peking University Shenzhen Medical University
-END-
Source: Peking University Shenzhen Hospital service number
Medical guidance: Chief Physician Lin Zhijian of Neurology of Peking University Shenzhen Medical University and attending physician Chen Xuhui
Doctor profile
Chen Xuhui
Shenzhen Peking University Shenzhen Hospital
Attending physician at the Department of Neurology
Deputy Secretary-General of the Chao Medical Association and member of the Dementia and Cognition Group of the Neurology Branch of the Shenzhen Medical Doctors Association. In 2010, he graduated from Harbin Medical University majoring in clinical medicine (seven-year program). After graduation, he worked in the Department of Neurology, Peking University Shenzhen Hospital. He has been engaged in this profession for more than 10 years. His main research areas are cognitive impairment and cerebrovascular diseases.
Chaozhou Medical Health Promotion Center - Chaozhou Medical Association was registered and established in Shenzhen in October 2016. It is an academic, public welfare and non-profit organization with offices in Guangzhou, Shantou, Foshan, Zhuhai, Dongguan, Zhongshan, Chaozhou and other places. There are branch centers. The Chaozhou Medical Association adheres to the purpose of "being kind-hearted and doing good to the world", and is committed to integrating superior medical resources, practicing public welfare and charity, establishing a service platform for great friendship, great health, and great development, repaying the society, and contributing to the construction of "health in the new era" "China Strategy" will do our best. At present, there are more than 4,000 individual members and more than 100 group members from home and abroad, covering almost all medical fields and specialties, including top hospitals and grassroots medical institutions at all levels, major medical schools, pharmaceutical companies and other units in the province. We sincerely invite outstanding medical workers and high-quality medical-related institutions to join the Chao Medical Association and work together to benefit the public and create brilliance!
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